Protein Alignment Rint1 and rint1

DIOPT Version :10

• Sequence 1: NP_648102.2
• Gene: Rint1 / 38807
• FlyBaseID: FBgn0035762
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_001038468.2
• Gene: rint1 / 562894
• ZFINID: ZDB-GENE-041210-174
• Length: 780
• Species: Danio rerio
• Alignment Length: 748
• Identity: 250/748 - (33%)
• Similarity: 375/748 - (50%)
• Gaps: 79/748 - (10%)

  Fly    12 IVARLNEEIGKDASQLHRASHLVSHY---KKHLQVLSQTLDYEDPQNVSCYKTAFQCQQQVCESI 73
            |||.:.:|||.|...|.:.|.|:...   .|.|:...||:....|..||....|.:..|:...|:
Zfish    40 IVALVQKEIGGDLKSLKKVSGLLEKLTLENKQLEEQVQTVSSSGPLRVSAALRAAEESQKKLGSL 104

  Fly    74 DFELEKLAHFEDKLKRKLKECQPVLEGVAEDLDKVRQLQRLQQYLLLVQDIQEISAALGNAINGK 138
             .|.|:|  ..:||::.|:..|...:.:.:.|.::..|::..:||..:..|:|:|.::...:...
Zfish   105 -LENERL--LSNKLQQHLQGAQVWTDSIGQVLGQLDTLEKHMKYLQCLARIEELSDSIQQYLMTN 166

  Fly   139 DE-------DKLVNIYLTLYEGNDCEHSVVGRLHAVQAQSLKSFAERTAIYWHKLLLKRLSSAFE 196
            ..       |.:.::.:.|.|.        |.||      |::|...|..:|||:|..:|:|.||
Zfish   167 SVWDAVRAIDSMASLDMDLRES--------GCLH------LQAFLRETLRFWHKILKDKLTSDFE 217

  Fly   197 AVLKSMRWAHLEQQALNYS---SARD-TAKAQLLAEYMF-------LIKSPAEERA-PLQSITPS 249
            .||..:.|..:.......|   :|:: .::.:||...:.       ||....|..: |.||.||
Zfish   218 EVLTQLHWPFISAPTQTLSPPANAQELNSQLELLVSQLLSLQTSDDLISENKETSSRPGQSQTP- 281

  Fly   250 IVCQPINRVVQLLLAPYRQRFQFHFTGTRQTNRLDKPEWFYTQILNWGKETHFFVGKTFQPAAIK 314
                |::..:|::|.|..:||::||||.||||.|.||||:.||||.|......|:.:..||...:
Zfish   282 ----PLSLPIQIMLLPLSKRFRYHFTGNRQTNSLSKPEWYLTQILIWMGNNSNFMDEKVQPILDR 342

  Fly   315 AGKLDYNLRLEFIRGLVQLAIEKLAVDIEQIAQDQILFAHLLDETLAFESELRETFGYPASFPSA 379
            ||. :.|.|:|..|||:.||.||||.|..::..|..||.||:||.|.||.|||.|..||.::|..
Zfish   343 AGG-NVNARVELCRGLLTLAQEKLAHDAPRLLYDDALFCHLVDEVLQFEKELRSTHSYPRAYPGV 406

  Fly   380 ISVITQPMYLLRWISLEERFCAEKMDDILQAETPF--QLIDPNSFENDLKIPKCADQFMRLLDAI 442
            :.::.:.....:|:|:|.:...||:|.:|.||..:  |..|....: :||.|.||:.||.||..|
Zfish   407 LHILLEESVFQKWLSVERKMAVEKVDAMLSAEGAWSSQYKDITDMD-ELKAPDCAETFMTLLLVI 470

  Fly   443 KDRYYGLIQPGHQLQFLHLQLELIDSFRQRLVQLHSSGAVPSI-----PILNAINYLVMVLREWG 502
            .:||..|.....||.||.||.||:|.||.||.|:....:...:     .||||.||:..||.:||
Zfish   471 TERYRSLPCQRAQLSFLALQKELVDDFRIRLTQVMKEESRQPLSSRYSAILNAANYISTVLSDWG 535

  Fly   503 ENVHYLHLHAA-------LAGP-NATEI-------NSVFEHAVAELEHWARQLMRNLATKATNEM 552
            :||.:|.|..|       :.|| .|||.       .|:||..:|.||.....::..|......::
Zfish   536 DNVFFLQLQQAAVSVGEEILGPLGATESGRLASLEGSLFEELLALLERLRGDMLGRLLDAVMRDV 600

  Fly   553 KAKSMSYRRDAWPTMPEQNSREPFILSPSGGEMFQVLVTLLHNLERELSANLFTQTLRLIAHQID 617
            |.|:..|.:|.|.::|.|:.:....||.|...|...|...|..|::.|...||....:.:|.::|
Zfish   601 KEKAQPYCKDRWISLPSQSDQATMSLSSSACPMMLCLRDHLLQLQQMLCLPLFQMFWQGLAERLD 665

  Fly   618 DFMLESMVMNTKFSAAGAAQFNYDMTRNLFALFGQYTRRPELLFKRTHDACKLLAAARGTALLLL 682
            .|:.|.:::...|:..||||..||||||||.|||.|.:|||..||...:||.:|....|.|||||
Zfish   666 CFIYEDLILYNHFNEGGAAQLQYDMTRNLFPLFGHYCKRPENFFKHVKEACIILTLKVGPALLLL 730

  Fly   683 ETLRGNQSVE------EKTKP---LRELHVLSM 706
            :.|:  ||.|      :::.|   |.||.:..:
Zfish   731 DVLK--QSEEDSLPNHQQSSPESALNELGIYKL 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rint1	NP_648102.2	RINT1_TIP1	260..718	CDD:461309	183/478 (38%)
rint1	NP_001038468.2	RINT1_TIP1	285..773	CDD:461309	183/481 (38%)