Protein Alignment Rint1 and Rint1

DIOPT Version :10

• Sequence 1: NP_648102.2
• Gene: Rint1 / 38807
• FlyBaseID: FBgn0035762
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_001386192.1
• Gene: Rint1 / 296750
• RGDID: 1560433
• Length: 792
• Species: Rattus norvegicus
• Alignment Length: 753
• Identity: 234/753 - (31%)
• Similarity: 373/753 - (49%)
• Gaps: 67/753 - (8%)

  Fly     7 EMELRIVARLNEEIGKDASQLHRASHLV-----SHYKKHLQVLSQTLDYEDPQNV-SCYKTAFQC 65
            |:.|.:.|.:.:|:|.|...|.....|:     |..|...|||  |:..|.|:.: |..|.|.:.
  Rat    51 ELLLYVSAFIEKEVGSDLKSLKTLGKLIEQMTESKVKLEEQVL--TISSEIPKRIQSALKDAEEA 113

  Fly    66 QQQVCESIDFELEKLAHFEDKLKRKLKECQPVLEGVAEDLDKVRQLQRLQQYLLLVQDIQEISAA 130
            :|.:.:.:..|    |.....:...|...||..:.:...:.::.:::|...||..|..|:|:|..
  Rat   114 KQALGDILGQE----APLFSSINSHLLIAQPWTDDLGAMISQIEEIERHLTYLKWVSQIEELSDN 174

  Fly   131 LGNAINGKDEDKLVNIYLTLYE------GNDCEHSVVGRLHAVQAQSLKSFAERTAIYWHKLLLK 189
            :...:......:..:..:|:.|      .:.|.|             |.||...|..:|:|:|..
  Rat   175 IQQYLMTNSVPEAASTLVTMTELDIKLQESSCTH-------------LLSFMRATVKFWYKILKD 226

  Fly   190 RLSSAFEAVLKSMRW---AHLEQQALNYSSARDTAKAQLLAEYMF--LIKSPAEERAPLQS-ITP 248
            :|:|.||.:|..:.|   .|.:.||:..|....|.:.....|.:|  |:|..|.:....:| ..|
  Rat   227 KLTSDFEEILAQLHWPFITHTQSQAVGASRPASTPETYASLETLFCQLLKLQASDELLTESKQLP 291

  Fly   249 SIVCQP----INRVVQLLLAPYRQRFQFHFTGTRQTNRLDKPEWFYTQILNW-GKETHFFVGKTF 308
            ...|.|    :...:|::|.|.::||::||.|:||||.:.||||::.|:|.| |..:| |:.:..
  Rat   292 EKYCLPASPSVALPIQIMLVPLQKRFRYHFRGSRQTNVISKPEWYFAQVLLWIGSHSH-FLDEKI 355

  Fly   309 QPAAIKAGKLDYNLRLEFIRGLVQLAIEKLAVDIEQIAQDQILFAHLLDETLAFESELRETFGYP 373
            ||...|.|.. .|.||||.||||.|.:||||.||..:..|..||.||:||.|.||.||....|||
  Rat   356 QPILDKVGSA-VNARLEFSRGLVMLILEKLASDIPCLLYDDSLFCHLVDEVLLFERELHSVHGYP 419

  Fly   374 ASFPSAISVITQPMYLLRWISLEERFCAEKMDDILQAETPF--QLIDPNSFENDLKIPKCADQFM 436
            ::|.|.:.::::.....||:::|.:|..:|||.:|.:|..:  |..|....: ::|:|.||:.||
  Rat   420 STFASCMHILSEETCFQRWLTVERKFALQKMDSMLSSEAAWVSQYKDITDVD-EMKVPDCAEVFM 483

  Fly   437 RLLDAIKDRYYGLIQPGHQLQFLHLQLELIDSFRQRLVQLHSSGAVPSI-----PILNAINYLVM 496
            .||..|.|||..|.....:||||.||.:|:|.||.||.|:........:     .||||:||:..
  Rat   484 TLLLVITDRYKNLPTASRKLQFLELQKDLVDDFRIRLTQVMKEETRAPLGFRYCAILNAVNYIST 548

  Fly   497 VLREWGENVHYLHL-HAAL-------------AGPNATEINSVFEHAVAELEHWARQLMRNLATK 547
            ||.:|.:||.:|.| .|||             .|..|:..:|||:..:..||.....::......
  Rat   549 VLADWADNVFFLQLQQAALEVFAENNVLSKLQLGQLASMESSVFDDMINLLERLKLDMLTRQVDH 613

  Fly   548 ATNEMKAKSMSYRRDAWPTMPEQNSREPFILSPSGGEMFQVLVTLLHNLERELSANLFTQTLRLI 612
            ...|:|..:..|:::.|.::..|:.:....||.|...:...|...|..||::|..:||....:::
  Rat   614 VFREVKDAAKLYKKERWLSLLSQSEQAVMSLSSSACPLLLTLRDRLLQLEQQLCFSLFNIFWQML 678

  Fly   613 AHQIDDFMLESMVMNTKFSAAGAAQFNYDMTRNLFALFGQYTRRPELLFKRTHDACKLLAAARGT 677
            ..::|.::.:.:::...|:..||||..:|||||||.||..|.:|||..||...:||.:|....|:
  Rat   679 VEKLDLYLYQEIILANHFNEGGAAQLQFDMTRNLFPLFSHYCKRPENYFKHVKEACIVLNLNIGS 743

  Fly   678 ALLLLETLRGNQSVEEKTKPLRELHVLSMDSKQCIEVL 715
            ||||.:.|:........|..|.|:.|..: ::|.:|:|
  Rat   744 ALLLKDVLQSASEHIPATAALNEVGVYKL-AQQDVEIL 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rint1	NP_648102.2	RINT1_TIP1	260..718	CDD:461309	171/478 (36%)
Rint1	NP_001386192.1	RINT1_TIP1	304..784	CDD:461309	171/478 (36%)