DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and ARHGEF39

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	XP_011516359.1	Gene:	ARHGEF39 / 84904	HGNCID:	25909	Length:	351	Species:	Homo sapiens

Alignment Length:	380	Identity:	90/380 - (23%)
Similarity:	159/380 - (41%)	Gaps:	55/380 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 GSPNPDAGKRLGFRRQ---AIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQIE 119
            ||..|...:|..:.|:   ..:|::.:|:.|.|||.|:..:|:..||.:..:.......|||..|
Human     7 GSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWE 71

  Fly   120 MIHNLNGEFLRELEA-----NMENVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRK 179
            :|:..:.|.|..||.     .:|....       ..:||:.:|.:...:...:|:.:.||..||:
Human    72 LIYGASQELLPYLEGGCWGQGLEGFCR-------HLELYNQFAANSERSQTTLQEQLKKNKGFRR 129

  Fly   180 FLEQTESRPEV-QRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHI 243
            |:...|.|||. ..:|..|:.:|:||:.:|:.|:..:...|.|...|::.|..:.:.|..||..:
Human   130 FVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRV 194

  Fly   244 NTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKGTEIKRYCVLMSDIFMYCK 308
            :|..::|:..|:|..:|..|..|....:...|..:::|.|..:...|....|...|.:|:.:
Human   195 HTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLL--- 256

  Fly   309 MIKERAP-NTVVENSLECCCIFPLKKCKVYEML-------PGNFKLTCQSDGIIFGSGDVQLSRT 365
            |.|.|.| :.:...:..|..::|:.:|.:..:.       .|...|...|.|..|
Human   257 MAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLLSLHGNSKGFSF---------- 311

  Fly   366 WVGFIRDAIDLHVQCRKTLRKDSSKRTPIRKKDMKKFGADYVLSP-NKRKCEYDT 419
                   ::||...|.|   :.|....|...:       .|.|.| .:|.|...|
Human   312 -------SLDLSEPCAK---RWSLSSCPSLMR-------SYCLCPQTRRSCHAGT 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	47/175 (27%)
		PH-like	269..>311	CDD:302622	8/41 (20%)
		PH	277..374	CDD:278594	18/104 (17%)
ARHGEF39	XP_011516359.1	RhoGEF	27..195	CDD:295373	47/174 (27%)
ARHGEF39	XP_011516359.1	PH-like	225..>269	CDD:302622	11/46 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H19225
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008364
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107378
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7163
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840