DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF4 and Arhgef11

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	XP_006232821.1	Gene:	Arhgef11 / 78966	RGDID:	619705	Length:	1577	Species:	Rattus norvegicus

Alignment Length:	695	Identity:	135/695 - (19%)
Similarity:	246/695 - (35%)	Gaps:	203/695 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FTPRQKGYGNGFIHSPQTPLSFSRE--LRQVLQERNLLTAKSRRKVCSMLDSNNSSPIGSPNPD- 63
            |||:.   |...|.||.  |.|..:  |..:|::                |....|.: .|.|:
  Rat   729 FTPKM---GRRSIESPN--LGFCTDVILPHLLED----------------DLGQLSDL-EPEPEV 771

  Fly    64 ------AGK--------RLGFRRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLL 114
                  .||        |...|::.|.|:..:|.|:|..|.:|...|.:.::::.::.......|
  Rat   772 QNWQHTVGKDVVANLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMRKENLMPREELARL 836

  Fly   115 FGQI-EM--IHNL----------NGEFLRELE----ANMENVAHAFLKM--APFFKLYSVYAFDY 160
            |..: |:  |||.          .|..:|::.    |..:..|...|:.  |.|....||
  Rat   837 FPNLPELIEIHNSWCEAMKKLREEGPIIRDISDLMLARFDGPAREELQQVAAQFCSYQSV----- 896

  Fly   161 RGALFIIQDLISKNPVFRKFLEQTESRPEVQR-KLNSLMIVPIQRVPRYKLLLEQVLLYTSPADA 224
              ||.:|:....|...|:.|:::.||.|:.:| :|..|::..:||:.:|.||||.::.:|....:
  Rat   897 --ALELIRTKQRKESRFQLFMQEAESHPQCRRLQLRDLIVSEMQRLTKYPLLLENIIKHTEGGTS 959

  Fly   225 DYKLLKESVKEIEATASHINTCVEEQE----ITQYLIHLQNSLVNRTPN--------IVKPSRRV 277
            :::.|..:..:.......:|..|::.|    :..|...|..:.:.|..|        :...:|::
  Rat   960 EHEKLCRARDQCREILKFVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKM 1024

  Fly   278 IKEGVLQKITHKGTEIKRYCVLMSDIFMYCKMIKER--------------------AP----NTV 318
            |.||.|.....|...:....:|:.|:.:..:..:||                    :|    |.|
  Rat  1025 IHEGPLTWRISKDKTLDLQVLLLEDLVVLLQRQEERLLLKCHSKTAVGSSDSKQTFSPVLKLNAV 1089

  Fly   319 VENSLE-------CCCIFPLKKCKVYEMLPGNFKLTCQSDGIIFGSGDVQLSRTWVGFIRDA--- 373
            :..|:.       ..|...|...::||::    .||.....|            |:..:.:|
  Rat  1090 LIRSVATDKRAFFIICTSELGPPQIYELV----ALTSSDKNI------------WMELLEEAVQN 1138

  Fly   374 ---------IDLHV----QCRKTLRKDSSKRTPIR-------KKDMKKF--GADYVLSPNKRKCE 416
                     |.:|.    ......:..:|.|..|.       :|:.||.  |.    .|.:|..:
  Rat  1139 ATKHPGAAPIPIHPSPPGSQEPAYQGSTSSRVEINDSEVYHTEKEPKKLPEGP----GPEQRVQD 1199

  Fly   417 YDTVFRNKNRSTDSEEETE---------DSACFSRKRKVASGILRAPNGNPM---GKASSSSSSS 469
            ...:.:.:....:.|||..         |..  :|..:....:|.|..| |:   |.|.::....
  Rat  1200 KQLIAQGEPVQEEDEEELRTLPRAPPSLDGE--NRGIRTRDPVLLALTG-PLLMEGLADAALEDV 1261

  Fly   470 VSMKRV-----------------APPPPAPPPPPAVQMRH---QPGRPGELATASKENRISKLYK 514
            .:::.:                 .|.....|.|..|.:..   .||.||:..|.|...|:::...
  Rat  1262 ENLRHLILWSLLPGHTVKTQAAGEPEDDLTPTPSVVSITSHPWDPGSPGQAPTISDSTRLARPEG 1326

  Fly   515 KIAAGDKVANVRGILKRSNVP----------APNNDHDPSYGFAS 549
            ....|:.||    :...:::|          :|..|.:|:...||
  Rat  1327 SQPEGEDVA----VSSLAHLPPRTRSSGVWDSPELDRNPAAEAAS 1367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	44/189 (23%)
		PH-like	269..>311	CDD:302622	9/49 (18%)
		PH	277..374	CDD:278594	22/139 (16%)
Arhgef11	XP_006232821.1	PDZ_signaling	63..128	CDD:238492
		DegQ	<78..154	CDD:223343
		flgC	269..>358	CDD:139220
		RGS_PDZRhoGEF	347..491	CDD:188707
		RhoGEF	796..980	CDD:279015	44/190 (23%)
		PH_PRG	997..1139	CDD:275426	26/157 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810