DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and Arhgef16

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_001121063.1	Gene:	Arhgef16 / 687105	RGDID:	1588981	Length:	709	Species:	Rattus norvegicus

Alignment Length:	269	Identity:	70/269 - (26%)
Similarity:	119/269 - (44%)	Gaps:	33/269 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQIEMIHNLNGEFLRELEAN 135
            |::||.||::||.|||..|::|:|.|::..:.:..:..:.|..||..|..:...:.:|...||..
  Rat   285 RQEAIFEILTSEFSYLHSLKILVNEFLQSQELKTTMTQTEHHHLFSNISDVLAASQKFFESLEQR 349

  Fly   136 ------MENVA-----HAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQTESRPE 189
                  :|:::     ||.....|:....|...:..|    .:|.|.:.|..||:.|.:.|..|.
  Rat   350 HKAQVCVEDISDILEDHAENHFHPYIAYCSNEVYQQR----TLQKLSNSNTAFREVLREIEKLPA 410

  Fly   190 V-QRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQEIT 253
            . ...:.|.:|:|:|||.|..||.:.:.|.|......||....::|.|.......|....:.|.|
  Rat   411 CGGLPMISFLILPMQRVTRLPLLTDTLCLKTQGHPERYKAASRALKAISKLVKQCNEGAHKMERT 475

  Fly   254 Q--YLIHLQNSL--VNRTPNIVKPSRRVIKEG---------VLQKITHKGTEIKRYCVLMSDIFM 305
            :  |.:|:|...  |...| ::..||.::|.|         :.:||..:.|   .|..|.:|:.:
  Rat   476 EQMYTLHMQLDFGKVKSLP-LISASRWLLKRGELLLLEESSIFRKIASRPT---CYLFLFNDVLV 536

  Fly   306 YCKMIKERA 314
            ..|...|.:
  Rat   537 VTKKKSEES 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	49/181 (27%)
		PH-like	269..>311	CDD:302622	11/50 (22%)
		PH	277..374	CDD:278594	10/47 (21%)
Arhgef16	NP_001121063.1	RhoGEF	288..466	CDD:395496	49/181 (27%)
		PH_ephexin	489..622	CDD:269929	14/61 (23%)
		SH3_ARHGEF16_26	633..684	CDD:212871
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810