Protein Alignment RhoGEF4 and arhgef19

DIOPT Version :9

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_005162265.1
• Gene: arhgef19 / 569202
• ZFINID: ZDB-GENE-090313-243
• Length: 958
• Species: Danio rerio
• Alignment Length: 381
• Identity: 83/381 - (21%)
• Similarity: 158/381 - (41%)
• Gaps: 69/381 - (18%)

  Fly    72 RQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQIEMIHNLNGEFLRELEANM 136
            ::|..|:::||.||:..|.:.::.|:...:....:.......||.::..:..::..||::||..:
Zfish   533 QEAKFELVTSEASYIRSLSIAVDHFMMSSELCECLGTQERQWLFSKLPDVKEVSERFLQDLERRL 597

  Fly   137 E------NVAHAFLKMAPFF-KLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQTESRPEVQR-K 193
            |      :|....|...|.. ::|..|..:........|.|:.:|..|...|.:.|..|..|| .
Zfish   598 EGDILRFDVCDIVLDHCPALRRVYLPYVTNQAYQEQTYQRLLQENARFPGILARLEEDPICQRLP 662

  Fly   194 LNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQEITQYLIH 258
            |.|.:|:|.||:.|.|:|:|.:|..|:|...|.....:::.|::......|:.|:..:..:.|||
Zfish   663 LTSFLILPFQRITRLKMLVENILKRTTPGSRDEDTATKALNELKKIIKECNSSVQSMKRMEELIH 727

  Fly   259 LQNSL--VNRTPNIVKPSRRVIKEGVL-----QKITHKGTEIK-----------RYCVLMSD--- 302
            |...:  ..:...::..||.::|.|.|     |.::..|::.|           ..|:|:|.
Zfish   728 LNKKIHFEGKIFPLISQSRWLVKHGELLEVDTQNLSISGSKFKLTTRPVYLHLFNDCLLLSRRKE 792

  Fly   303 -----IFMYCKM----IKERAPNTVVENSLECCC--IFPLKKCKVYEMLPGNFKLTCQSDGIIFG 356
                 :|::.|:    :|:      :...|:...  ||.|:.|:..::          ...|:..
Zfish   793 SWKFMVFVHAKIEDLKVKD------LSQKLQGISGFIFYLQLCEGQQL----------KHQILLK 841

  Fly   357 SGDVQLSRTWVG--FIRD---AI-------DL-HVQCRKTLRKDSSKRTPIRKKDM 399
            |......:.|:.  |..|   ||       || .|||.::.:........:.|.|:
Zfish   842 SPTESSKQRWITAMFPSDPTTAIEQTNENDDLSQVQCIRSYQAQEHDELTLEKADI 897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	44/177 (25%)
		PH-like	269..>311	CDD:302622	13/69 (19%)
		PH	277..374	CDD:278594	22/131 (17%)
arhgef19	XP_005162265.1	RhoGEF	537..713	CDD:279015	43/175 (25%)
		PH_ephexin	735..862	CDD:269929	24/142 (17%)
		PH	748..855	CDD:278594	20/122 (16%)
		SH3_ARHGEF5_19	875..929	CDD:212873	5/23 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810