Protein Alignment RhoGEF4 and arhgef16

DIOPT Version :9

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_005167338.1
• Gene: arhgef16 / 567180
• ZFINID: ZDB-GENE-081104-446
• Length: 662
• Species: Danio rerio
• Alignment Length: 411
• Identity: 104/411 - (25%)
• Similarity: 169/411 - (41%)
• Gaps: 76/411 - (18%)

  Fly    22 SFSRELR--QVLQERNLLTAKSRRKVCSM-LDSNNSSPIGSPNPDAG------------------ 65
            ||..|.|  |.::||.|       .|.|: .:....||:|.|..|.|
Zfish   178 SFKDEPRFYQEIKERGL-------NVSSLSTEEEELSPVGPPGEDQGIVVKNYRAAYITWSQLPQ 235

  Fly    66 -KRLGF----------RRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQIE 119
             |.||.          |::.|.|||:||.||...|.:|:..|...:..:..:..:.|..||..|.
Zfish   236 VKDLGILDFITPEERKRQEVIFEIITSEYSYQHSLSILVRHFKDSVDLRKTMTATEHHHLFSNIS 300

  Fly   120 MIHNLNGEFLREL----EAN--MENVAHAFLKMA-PFFKLYSVYAFDYRGALFIIQDLISKNPVF 177
            :|.:::..|..:|    :||  :|.::......| ..|:.|.||..:.......:|.|:|.|..|
Zfish   301 VIQDVSKRFFEDLDKRHQANPVIERISDIVATYATKHFEPYIVYCSNETFQQRTLQKLLSSNSAF 365

  Fly   178 RKFLEQTESRPEV-QRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATAS 241
            |:.|:|.|:..:. ...:.|.:|:|:|||.|..||::.:...|:...|:|.....:.|.|.....
Zfish   366 RETLKQIETSEDCGGLPMLSFLILPMQRVTRLPLLMDTICEKTTKETAEYYKACWAFKAISKLVK 430

  Fly   242 HINTCVEEQEITQYLIHLQNSL----VNRTPNIVKPSRRVIKEGVLQ------KITHKGTEIKRY 296
            ..|......|.|:.:..:|..:    :...| :|..||.:.|.|.|.      .|..|....|.|
Zfish   431 SCNDGARRMERTEQMYTIQKQMEFGKIKPFP-LVSSSRWLKKSGELAVYTDDLSIFRKAFSFKSY 494

  Fly   297 CV-LMSDIFMYCKMIKERAPNTVVENSLECCCIFPLKKCKVYEMLPG---NFKLTC--QSDG--- 352
            .: |.:|:.:..|  |:...:.||   |:...:   :|.:|.|.:..   |.||..  .|||
Zfish   495 YLFLFNDVLIVTK--KKSEESYVV---LDYATV---EKVEVEEEMSDSKLNLKLMMNPNSDGRSE 551

  Fly   353 -IIFGSGDVQLSRTWVGFIRD 372
             ::..:.:..:...||..:||
Zfish   552 QLVLVAENKLVRAQWVTALRD 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	49/177 (28%)
		PH-like	269..>311	CDD:302622	13/48 (27%)
		PH	277..374	CDD:278594	27/112 (24%)
arhgef16	XP_005167338.1	RhoGEF	255..434	CDD:279015	49/178 (28%)
		PH_ephexin	456..577	CDD:269929	31/126 (25%)
		PH	469..574	CDD:278594	27/112 (24%)
		SH3_ARHGEF16_26	586..639	CDD:212871

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910