DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and arhgef11

DIOPT Version :9

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_001027010.1 Gene:arhgef11 / 565268 ZFINID:ZDB-GENE-070604-1 Length:1417 Species:Danio rerio


Alignment Length:795 Identity:155/795 - (19%)
Similarity:269/795 - (33%) Gaps:202/795 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 FTPR------------QKGYGNGFIHSPQTPLSFSRELRQVLQERNLLTAKSRRKVC-------- 46
            |.||            ::|.|...:|...:..:.|...|.:.......|.:|:|::.        
Zfish   636 FVPRSRSDVDMEDCEEREGPGLRPLHHSASSSASSSSARSLENPTPPYTPRSQRRIVEVPVSLLP 700

  Fly    47 -------SMLDSNNSSPIGSPNPDAG--KRLGFRRQAIQEIISSEKSYLEQLELLMNFFVRPLKE 102
                   .::||:|......|:..|.  .|...|:..|.|:.::|.|:|..|.:|...|.:  |.
Zfish   701 DAPALDEDVIDSHNWQDTVEPHILASLTSREIDRQAVIYELFTTEVSHLRTLRVLDQVFYQ--KM 763

  Fly   103 QAIIDCSNHTLLFGQIEMIHNLNGEFLREL----------------------EAN---MENVAHA 142
            |:::.....:.:|..:..::.|:......:                      ||.   .|.|:|.
Zfish   764 QSVLSPEELSCIFLNLRQVYELHASLCESMKKCRESVIVQGIGDIMLARFEGEAGDQFEEQVSHL 828

  Fly   143 FLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQTESRPEVQR-KLNSLMIVPIQRVP 206
            ..:.:|              ||.:|::...|:|.|...:::.|:.|..:| :|..|::..:||:.
Zfish   829 CSQQSP--------------ALELIKNKQRKDPRFAHLIQECEASPHCRRLQLKDLLVSEMQRLT 879

  Fly   207 RYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQE----ITQY--------LIHL 259
            :|.|||:.::.||..:..|..||:.:..........:|..|.|.|    ::||        |..|
Zfish   880 KYPLLLDNIIKYTETSSPDLPLLRRAQACCRGILQEVNEDVRETEHRHLLSQYQRRLDATPLERL 944

  Fly   260 QNSLVNRTPNIVKPSRRVIKEGVLQKITHKGTEIKRYCVLMSDIFMYCKMIKERAPNT------- 317
            .|.:..:..|:...::|::.||.|.....|...|:...:|:||:.    ::.:|.|:.       
Zfish   945 ANPVAAQFRNLDLTTKRMVHEGPLTWRVGKDKAIEIQALLLSDLL----LLLQRGPDDRLILRCP 1005

  Fly   318 ------VVENSLECCCIFPLKKCKVYEMLPGNFKL----TCQSDGIIFGSGDVQLSRTWVGFIRD 372
                  |.:.....|.:..|..|.|..:...|..|    |.:.......:|.:....||...:..
Zfish  1006 SRSLGGVTDLKTPFCPVVCLDSCLVRPVATDNKALYVISTSERQIYELVAGTLLEKNTWKDQLEK 1070

  Fly   373 AIDLHVQCRKTLRKDSSKRTP---IRKKDMKKFGADYVLSPNKRKCEYDTVFRNKNRSTDSEEET 434
            .|....|...|.......|:|   :|....:..|::..:.|::   |.:.|........|:.||.
Zfish  1071 TISAAAQGGSTKPNTPRFRSPGAGVRLSADQSEGSESRMYPDR---EDEMVLSPVVTPADAAEEC 1132

  Fly   435 ED---SACFSRKRKVASGIL---------------------------------RAPNGNPMGKAS 463
            .|   ......|..||...|                                 |:|..:..|..|
Zfish  1133 PDEDPDPGQKNKAGVAESALQDVETLRQLIFRDLEDGWSQDSDDTPTNETANERSPFTDRPGNES 1197

  Fly   464 SSSSSSVSMKRVAPPPPAPPP----PPAVQ-MRHQPG----RPGEL---ATASKENRI-SKLYKK 515
            |..:.|.|..:....|...||    .|||| :|...|    .|.::   .|||:.:.. ..|:..
Zfish  1198 SDPAPSESSSQWEEEPVEAPPLEVLQPAVQVVRKAVGVGCSLPDDITDDVTASQSSEDGGNLFYL 1262

  Fly   516 IAAGDKVAN-----------VRGILKRSNVPAPNNDHDP-----------SYGFASRYSDSKSYF 558
            :.:.|:|.:           ...:...|.:........|           |.|.....|.|:|..
Zfish  1263 VMSTDQVVSDESTTDELKDLHHSVFSSSFINEEEEQDTPCLSPTDQSLIESQGHRPGLSQSQSSV 1327

  Fly   559 RAHNVDNTIPTFVKREDLFNGDNMFPVHLKSHEEICTPPQKKRVKFDDTLDAVSPVLVEKPFAFS 623
            :.|.:.|....|...|:|.....    ||:..|.......||               :.||....
Zfish  1328 QRHVIKNVDEIFNTMEELMKKLQ----HLRDIEADHHKLLKK---------------LRKPLPVD 1373

  Fly   624 SESSSAL--KPTSLR 636
            ..||..:  .||:.|
Zfish  1374 KMSSDGVHKSPTAAR 1388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:279015 40/195 (21%)
PH-like 269..>311 CDD:302622 10/41 (24%)
PH 277..374 CDD:278594 21/113 (19%)
arhgef11NP_001027010.1 PDZ_signaling 49..123 CDD:238492
DegQ <71..140 CDD:223343
RGS_PDZRhoGEF 300..446 CDD:188707
RhoGEF 737..918 CDD:279015 40/196 (20%)
PH-like 935..1075 CDD:302622 27/143 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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