DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and plekhg7

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_001315140.1	Gene:	plekhg7 / 562798	ZFINID:	ZDB-GENE-070410-15	Length:	769	Species:	Danio rerio

Alignment Length:	441	Identity:	83/441 - (18%)
Similarity:	167/441 - (37%)	Gaps:	112/441 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 RQAIQEIISSEKSY-LEQLELLMNFFVRPLKE----QAIIDCSNHTLLFGQIEMIHNLNGEFLRE 131
            ::||.|:.:||..| |:||.:|...|:..|.:    |.:.|..:.. ||..:..:..::..||..
Zfish   373 QEAIWELFTSECVYFLDQLMVLKEVFLTTLSDLQTRQCLQDIDSWR-LFANLNELCLVSFGFLTS 436

  Fly   132 L------------------------EANMENVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLIS 172
            |                        :|..|::.|...|          |..:|..|:..: |.:.
Zfish   437 LLRVIKEMWTDPDSCSTQSLHDLFRKAFSESICHCLQK----------YCLNYSTAILYL-DSLK 490

  Fly   173 KNPVFRKFLEQTESRPEVQR-KLNSLMIVPIQRVPRYKLLLEQV-LLYTSPADAD-----YKLLK 230
            ....|..|::..|...|.:| :|..|::||:||..||.|||:.: ....|.|:.:     ..|:.
Zfish   491 LREDFGSFVKWCERNEECRRLQLKDLLVVPLQRFTRYPLLLKNIGKRSCSKAEENTIQSIVDLVD 555

  Fly   231 ESVKEIEATASHINTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKGTEIKR 295
            .::.::|.....::...:.:::.:.|:.|.....::..::.:..:.::|...|:.:.     |.|
Zfish   556 RAIYDLEGKVKWLDNYQKVKQLKETLVWLPVWESDKRAHVPESLKHLLKPVTLENLV-----INR 615

  Fly   296 YCVLMSDIFMYCKMIKERAPNTVVENSLECCCIFPLKKCKVYEMLPGNFKLTC-------QSDGI 353
            ..:....:|:             :||:         |:.:||..|...|.|..       |..|:
Zfish   616 SLLHDGKLFL-------------IENT---------KQQEVYLFLFDEFLLITKIKRNKKQKSGV 658

  Fly   354 I-FGSGDVQLSRTWVGFIRDAIDLHVQ--CRKTLRKDSSKRTPIRKKDMKKFGADYVLSPNKRKC 415
            : |.:|             ..::|.:|  |..|:.........::.|::.:..|.....||
Zfish   659 VDFAAG-------------QELELLLQEGCSFTVLDQPISLDRLQLKNIDQLNATASTLPN---- 706

  Fly   416 EYDTVFRNKNR--------STDSEEETEDSACFSRKRKVASGILRAPNGNP 458
              ..:..::||        ...::.|:...|..|...|..|.:|:..:.:|
Zfish   707 --SFIIMHQNRYQQCIAVFVLQAQSESTKKAWMSEIEKAVSSLLKQDSLHP 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	47/205 (23%)
		PH-like	269..>311	CDD:302622	5/41 (12%)
		PH	277..374	CDD:278594	17/104 (16%)
plekhg7	NP_001315140.1	DUF4675	122..>245	CDD:292348
		RhoGEF	375..538	CDD:279015	43/174 (25%)
		PH_PLEKHG7	616..741	CDD:270065	26/165 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810