DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and arhgef2

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	XP_021328624.1	Gene:	arhgef2 / 561276	ZFINID:	ZDB-GENE-030717-1	Length:	872	Species:	Danio rerio

Alignment Length:	287	Identity:	61/287 - (21%)
Similarity:	131/287 - (45%)	Gaps:	38/287 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 NSSPIGSPNPDAGKRLGFRRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQ 117
            :||.:.|...|..|    |:..|.|:|.:|.:::..|.::...|.|.:.|:.:::......:|..
Zfish   230 DSSYLQSQRKDVIK----RQDVIYELIQTEFNHVRTLRIMEGVFRRGMLEEVMMEMGVVHAIFPC 290

  Fly   118 IEMIHNLNGEFLREL-------EANMENVAHAFLKMAPFF-------------KLYSVYAFDYRG 162
            ::.:..::..||.:|       .|:..|......|:....             |.|..:...:..
Zfish   291 LDQLLLIHTNFLSQLLQRRSNSLASNSNRNFTIQKLGDILVEQFSGQNAEDMRKCYVEFCSRHLK 355

  Fly   163 ALFIIQDLISKNPVFRKFLEQTESRPEVQRK--LNSLMIVPIQRVPRYKLLLEQVLLYTSPADAD 225
            |:.:.::|::::..|::|:.:. ||..:.|:  :...:::..||:.:|.:|::::|..|...:.:
Zfish   356 AVKLYKELLARDKRFQQFIRRV-SRGSLLRRHGVQECILLVTQRITKYPVLMQRILDNTKGNEEE 419

  Fly   226 YKLLKESVKEIEATASHINTCVEEQEITQYLIHLQNSLVNRTPNIVKPS----------RRVIKE 280
            .|.|.:|:..|......::..|:|.|..|.|..:|:.|..|....||..          |.:|.|
Zfish   420 SKSLAQSLTLIRELLCSVDQQVQELERAQRLQEIQSRLDPRAETKVKGGGVFHGAELLRRGLIHE 484

  Fly   281 GVLQKITHKGTEIKR-YCVLMSDIFMY 306
            |.|...|.:|:.:|. :.:||:|:.::
Zfish   485 GALLWKTAQGSRLKDVHVLLMTDVLVF 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	34/191 (18%)
		PH-like	269..>311	CDD:302622	13/49 (27%)
		PH	277..374	CDD:278594	10/31 (32%)
arhgef2	XP_021328624.1	C1	47..92	CDD:237996
		RhoGEF	244..438	CDD:238091	35/194 (18%)
		PH-like	478..595	CDD:327399	11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810