Protein Alignment RhoGEF4 and fgd1

DIOPT Version :9

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_688794.4
• Gene: fgd1 / 560305
• ZFINID: ZDB-GENE-081104-33
• Length: 995
• Species: Danio rerio
• Alignment Length: 408
• Identity: 104/408 - (25%)
• Similarity: 183/408 - (44%)
• Gaps: 76/408 - (18%)

  Fly    50 DSNNSSPIG-SPNPDAGKRLGFRRQAIQ--------EIISSEKSYLEQLELLMNFFVRPLKEQA- 104
            |.:..:|:. .|.|.| :|......::|        |::.:||:|:.:|.||...|...|.|:|
Zfish   390 DESEMNPMALQPLPKA-ERQDSTEMSVQQRVFNIANELLHTEKAYVSRLHLLDQVFCAQLMEEAR 453

  Fly   105 ---IIDCSNHTLLFGQIEMIHNLNGEF-LRELEANME------NVAHAFLKMAPFFKLYSVYAFD 159
               ...|.....:|..|..|:..:.:| |..||..||      .:.....|:|||.|:|..|..:
Zfish   454 ARSSFPCEMVMGIFSNICSIYCFHQQFLLPALEKRMEEWDLNPRIGDILQKLAPFLKMYGEYVKN 518

  Fly   160 YRGALFIIQDLISKNPVFRKFLEQTESRPEVQRK-------LNSLMIVPIQRVPRYKLLLEQVLL 217
            :..|:.::...:.::..|:..:.      .:|::       |...|:.|:||:|||:|||:. .|
Zfish   519 FDRAMELVNTWMQRSSQFKTIIH------NIQKEEMCGNLTLQHHMLEPVQRIPRYELLLKD-YL 576

  Fly   218 YTSPADA-DYKLLKESVKEIEATASHINTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEG 281
            :..|.|| |:|..::|::.|...|.|.|..:.:.|..:.|:.:. .|:....:||.|:..:||||
Zfish   577 HRLPEDADDFKDAQKSLELIATAAEHSNAAIRKMERMRKLLKVY-ELLGGEEDIVNPTNELIKEG 640

  Fly   282 VLQKITHK-GTEIKRYCVLMSDIFMYC----KMIKE----RAPNTVVENSLECCCIFPLKKCKVY 337
            .:.|::.| ||...||.:|.:|..:||    ::|.:    ||...|  :.:|      ||:....
Zfish   641 HILKLSAKNGTSQDRYLILFNDRLLYCVPKLRLIGQKFGVRARIDV--DGME------LKETSSM 697

  Fly   338 EMLPGNFKLTCQSDGIIFGSGDVQLSRTWVGFIRDAIDLHVQCRKTLR----------------- 385
            . :|..|.::.:...:...:...:..|.|:..|:..|..|.|..:|.|
Zfish   698 N-VPRTFLVSGKQRSLELQARTEEEKRDWIQAIQATIQRHEQTLETFRMLNCSFREEDLTPPNSP 761

  Fly   386 --KDSSKR--TPIRKKDM 399
              .:..||  ||||:|::
Zfish   762 NCSELGKRAPTPIREKEV 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	53/196 (27%)
		PH-like	269..>311	CDD:302622	17/46 (37%)
		PH	277..374	CDD:278594	26/105 (25%)
fgd1	XP_688794.4	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X316
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910