Protein Alignment RhoGEF4 and si:ch73-15b2.5

DIOPT Version :9

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_686873.2
• Gene: si:ch73-15b2.5 / 558551
• ZFINID: ZDB-GENE-030131-5406
• Length: 532
• Species: Danio rerio
• Alignment Length: 255
• Identity: 68/255 - (26%)
• Similarity: 127/255 - (49%)
• Gaps: 24/255 - (9%)

  Fly    72 RQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQIEMIHNLNGEFLRELEAN- 135
            ::|:.|:|.||.||.:.|.:.:|.|....:.:.|:....|.:||..::.:..::..||::||::
Zfish   208 QEAMFELIVSEASYQKSLIVALNVFQCSAELKHILTRVQHHVLFSNLKDVCRVSERFLQDLESHL 272

  Fly   136 -----MENVAHAFLK-MAPFFKLYSVYAFD--YRGALFIIQDLISKNPVFRKFLEQTESRPEVQR 192
                 |..|....|. ...|.::|..|..:  |:.||  :..|:.:|..|...|::.|..|:.||
Zfish   273 RQDVVMSQVGDVVLNHQKSFQQVYVPYITNMMYQEAL--VTQLLQENRKFAPILKKLEKDPQCQR 335

  Fly   193 K-LNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQEITQYL 256
            : |.|.:|:|.||:.|..||||.||........:...:||:::.:.......:|.|::.:.|:.|
Zfish   336 QTLKSFLILPFQRITRITLLLENVLKRARGVSLNVPNVKEAIEAVRKIVEECDTRVQKMKRTELL 400

  Fly   257 IHLQNSL----VNRTPNIVKPSRRVIKEGVLQKI----THKGTEIKR---YCVLMSDIFM 305
            :.|...:    |...|.|.: .|.:::||.|:::    .||.:.:.|   |..|.:|:.:
Zfish   401 VSLDKLVDFGNVKAVPLITR-GRHLVQEGTLKQLIIGGNHKASIVSRKDLYIHLFNDLLL 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	50/179 (28%)
		PH-like	269..>311	CDD:302622	11/44 (25%)
		PH	277..374	CDD:278594	9/36 (25%)
si:ch73-15b2.5	XP_686873.2	RhoGEF	210..388	CDD:279015	50/179 (28%)
		PH-like	412..532	CDD:302622	13/49 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810