| Sequence 1: | NP_648101.1 | Gene: | RhoGEF4 / 38806 | FlyBaseID: | FBgn0035761 | Length: | 647 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_060821.3 | Gene: | FGD6 / 55785 | HGNCID: | 21740 | Length: | 1430 | Species: | Homo sapiens |
| Alignment Length: | 564 | Identity: | 126/564 - (22%) |
|---|---|---|---|
| Similarity: | 220/564 - (39%) | Gaps: | 146/564 - (25%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 50 DSNNSSPIGSPNP-------DAGKRLGFRRQAIQEIISSEKSYLEQLELL-MNF----------F 96
Fly 97 VRPLKEQAIIDCSNHTLLFGQIEMIHNLNGEFLRELEANM------ENVAHAFLKMAPFFKLYSV 155
Fly 156 YAFDYRGALFIIQDLISKNPVFRKFLEQTESRPE-VQRKLNSLMIVPIQRVPRYKLLLEQVLLYT 219
Fly 220 SPADADYKLLKESVKEIEATASHINTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQ 284
Fly 285 KITHKGTEIKRYCVLMSDIFMYCKMIKERAPNTVVENSL-ECCCIFPLKKCKV----YEMLPGNF 344
Fly 345 KLTCQSDGIIFGSGDVQLSRTWVGFIRDAIDLHVQCRKTL-------RKDSSKR---TPIRKK-- 397
Fly 398 --------------------------------------DMKKFGADYVLSPNKRKCEYDTVFRNK 424
Fly 425 NRSTDSEEETEDSACFSRKRKVASGILRAPN-GNPMGKASSSSSSSVSMKRVAPPPPAPPPPPAV 488
Fly 489 QMRHQPGRPGELATASKENRISKLYKKIAAGDKVANVRGILKRS 532 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| RhoGEF4 | NP_648101.1 | RhoGEF | 74..244 | CDD:279015 | 51/187 (27%) |
| PH-like | 269..>311 | CDD:302622 | 14/41 (34%) | ||
| PH | 277..374 | CDD:278594 | 20/101 (20%) | ||
| FGD6 | NP_060821.3 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..36 | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 330..351 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 516..538 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 695..739 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 800..869 | 7/23 (30%) | |||
| RhoGEF | 875..1059 | CDD:279015 | 51/189 (27%) | ||
| PH1_FGD6 | 1077..1199 | CDD:275436 | 30/132 (23%) | ||
| PH | 1092..1183 | CDD:278594 | 21/100 (21%) | ||
| FYVE_FGD6 | 1217..1277 | CDD:277282 | 7/80 (9%) | ||
| PH | 1336..1426 | CDD:278594 | 4/8 (50%) | ||
| PH2_FGD5_FGD6 | 1336..1424 | CDD:270057 | 4/8 (50%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X316 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.870 | |||||