DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF4 and fgd6

DIOPT Version :9

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_001093450.1 Gene:fgd6 / 556459 ZFINID:ZDB-GENE-041210-200 Length:1315 Species:Danio rerio


Alignment Length:582 Identity:132/582 - (22%)
Similarity:234/582 - (40%) Gaps:140/582 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 EIISSEKSYLEQLELLMNFF-----------VRPLKEQAIIDCSNHTLLFGQIEMIHNLNGEFLR 130
            ||:||||.:::.|:||...|           .:||.|:.::   |..|.:  :..::.||.:.|:
Zfish   776 EIMSSEKVFVDVLKLLHIDFRDAVAKATRASGKPLVEEKVL---NQILYY--LPQLYELNKDLLK 835

  Fly   131 ELEANMENVAH---------AFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQTES 186
            |||   |.|||         .|::..|:.|:||.|..::...:.::.:...|||.|...:.|.|:
Zfish   836 ELE---ERVAHWSDHQRLADIFVQKGPYLKMYSTYIREFDRNVALLDEQCRKNPPFSSVVRQFET 897

  Fly   187 RPE-VQRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQ 250
            .|. ....|...::.|:||:|:|:|||...|.......:|||..:.::..::..|:|.|..:::.
Zfish   898 SPRCASLALKHYLLKPVQRIPQYQLLLTDYLKNLPEDSSDYKDTQTALSVVKEVANHANDIMKQG 962

  Fly   251 EITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKGTEIKRYCVLMSDIFMYCKMIK---- 311
            :..|.|:.:|.|| |....||:|.|..:|||.|.|::.|..: .|...|.:||.:|...::    
Zfish   963 DNFQKLMQVQYSL-NGHHEIVQPGRVFLKEGTLMKLSRKVMQ-PRMFFLFNDILLYTTPVQSGQY 1025

  Fly   312 ------------------------------ER----APNTVVENS--LECCCI----FPLKKCKV 336
                                          ||    :.|:..|..  ||....    :..||...
Zfish  1026 KVNSMLSLAGMKVSKPSQEAYQNELNIESVERSFILSANSATERDEWLEAIATAIDDYTRKKISF 1090

  Fly   337 Y----EMLPGNFKLTCQSDGIIFGSGDVQLSRTWVGFIRDAIDLHVQCRKTL--RKDSSK---RT 392
            :    :.|.|     ...||:..||    .:..|:..:|..:.:...|..||  |:...:   :.
Zfish  1091 FSSRSQELEG-----ISDDGLPLGS----KAPIWIPDLRTTMCMICTCEFTLTWRRHHCRACGKV 1146

  Fly   393 PIRKKDMKKFGADYVLSPNKRKCEYDTV-FRNK---NRSTDSEEETEDSACFSRKRKVASGILRA 453
            ..:.....||..:|:.:...|.|::..: .::|   :..|.|......:..||||:|.....|:.
Zfish  1147 VCQACSSNKFYLEYLKNQLARVCDHCYIKLQHKGDQSNVTFSPSGRGSTFAFSRKQKKIPSALKE 1211

  Fly   454 PNGNPMGKASSSSSSSVSMKRVAPPPPAPPPPPAVQMRHQPGRPGELATASKENRISKLYKKIAA 518
            .:.|     :.:||.|..:.|              ...|:  :|.:......:|::...|   ||
Zfish  1212 VSAN-----TENSSMSGYLHR--------------SKGHK--KPWKRLWFVIKNKVLYTY---AA 1252

  Fly   519 GDKVANVRGILKRSNVPAPNNDHDPSYGFASRYSDS----KSYFRAHNVDNTIPTFVKREDL 576
            .:.||.:              :..|..||..|...:    |..|:.:: .||:....:.||:
Zfish  1253 SEDVAAL--------------ESQPLLGFFLREEKTGPAQKLQFKLYH-KNTLYYIFRAEDI 1299

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:279015 53/187 (28%)
PH-like 269..>311 CDD:302622 15/41 (37%)
PH 277..374 CDD:278594 27/144 (19%)
fgd6NP_001093450.1 DUF4775 <93..327 CDD:292620
RhoGEF 773..957 CDD:279015 53/188 (28%)
PH-like 975..1097 CDD:302622 25/123 (20%)
PH 990..1080 CDD:278594 17/90 (19%)
FYVE_FGD6 1113..1173 CDD:277282 11/59 (19%)
PH 1221..1313 CDD:278594 20/113 (18%)
PH2_FGD5_FGD6 1221..1309 CDD:270057 20/113 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X316
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

Return to query results.
Submit another query.