Protein Alignment RhoGEF4 and si:dkey-91i10.2

DIOPT Version :9

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_005167625.1
• Gene: si:dkey-91i10.2 / 555224
• ZFINID: ZDB-GENE-050208-441
• Length: 1121
• Species: Danio rerio
• Alignment Length: 459
• Identity: 92/459 - (20%)
• Similarity: 179/459 - (38%)
• Gaps: 99/459 - (21%)

  Fly    39 AKSRRKVCSMLDSNNSSPIGSPNPDAGKRLGF---------------RRQAIQEIISSEKSYLEQ 88
            |:|.|:   .|.|..:..:..|.||.|.:.|.               |::||.|.:::|.||.|.
Zfish   690 ARSWRR---PLPSLRTWDVQQPCPDCGHKEGAHGEGMCERCSKLRTERKEAILEFLNTESSYGED 751

  Fly    89 LELLMNFFVRPLKEQAIIDCSNHTLLFGQIEMIHNLNGEFLRELEANMEN-------------VA 140
            |.::...|..|::...::......::|..::.:.::|.:|...|:.:::.             :.
Zfish   752 LRIIKEEFYCPMQSAGLLTAEQLAVVFSNVQELIDVNEKFTEHLQDSIDQAFDQGDEDLQAVCIG 816

  Fly   141 HAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQTESRPEVQRKLN--SLMIVPIQ 203
            ..||:.......:..|......::.::..|..:..:.|.||:.:::.....|::|  |.::.|:|
Zfish   817 EIFLEFVNMLPAFQTYCLQQSTSVNMLNTLEKEKELLRIFLDVSQNDNTALRRMNLRSFLMAPLQ 881

  Fly   204 RVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQEITQYLIH--LQNSLVNR 266
            ||.:|.|||.::...|:....||..|||:...:|:...|||...:::....:.:.  .::|..||
Zfish   882 RVTKYPLLLSRISKATNECHPDYPRLKEAKSRVESHLEHINMKTKQEGTATWSLRSFRRDSRKNR 946

  Fly   267 -TPNI------------VKPSRRVIKEGVLQ-------KITHKGTEIKRYCVLMSDIFMYCKMIK 311
             ..||            .:.|.|.|.||.||       :...||::..::..:.|.:     |::
Zfish   947 EVINIEMRELSMKMVGWARESTRFIMEGPLQLAQPADGQWLKKGSKSLKFQNVQSLL-----MVR 1006

  Fly   312 E-RAPNTVVENSLECCCIFPLKKCKVYEMLPGNFKLTCQSDGIIF-----GSGDVQLSRTWVGFI 370
            . ||.:.|.:.|||                    ......||::.     .||...:.|..:...
Zfish  1007 TLRATDAVPDGSLE--------------------SSEAVQDGVLVLIKDKSSGKFTVLREPIRLA 1051

  Fly   371 RDAIDLHVQCRKT------------LRKDSSKRTPIRKKDMKKFGADYVLSPNKRKCEYDTVFRN 423
            ...:.:...|..|            .|.....||....:.:|::..| :.|..||:.....:..|
Zfish  1052 NCVVSVDPDCEDTFEVLDIRREAFVFRASDKPRTQQWFRQVKRYVCD-LGSWRKRRNALPNIMIN 1115

  Fly   424 KNRS 427
            .::|
Zfish  1116 TSQS 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	40/184 (22%)
		PH-like	269..>311	CDD:302622	13/60 (22%)
		PH	277..374	CDD:278594	20/109 (18%)
si:dkey-91i10.2	XP_005167625.1	RhoGEF	737..922	CDD:279015	40/184 (22%)
		PH	<1025..1094	CDD:214574	10/68 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810