DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and ARHGEF38

DIOPT Version :9

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_001229658.1 Gene:ARHGEF38 / 54848 HGNCID:25968 Length:777 Species:Homo sapiens


Alignment Length:749 Identity:154/749 - (20%)
Similarity:267/749 - (35%) Gaps:252/749 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 ELRQVLQERNLLTAKSRRKVCSMLDSNNSSPIGSPNPDAGKRLGFRRQ-AIQEIISSEKSYLEQL 89
            |..|.|||:  :|.:....|...|.......:        ||:..:|: .|:|:|.:||.||..|
Human    59 EYNQKLQEK--MTPQGECSVAETLTPEEEHHM--------KRMMAKREKIIKELIQTEKDYLNDL 113

  Fly    90 ELLMNFFVRPLKEQAI--IDCSNHTLLFGQIEMIHNLNGEFL-------RELEANMENVAHAFLK 145
            ||.:...|:||:.:..  :|..:   ||..||.:|.::.:.|       .::|..|:.:...||:
Human   114 ELCVREVVQPLRNKKTDRLDVDS---LFSNIESVHQISAKLLSLLEEATTDVEPAMQVIGEVFLQ 175

  Fly   146 M-APFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLE----------QTESRPEVQRKLNSLMI 199
            : .|...:|.:|.:.:..|..|::. ..|....::.|.          ..|.:|.: ..:.||||
Human   176 IKGPLEDIYKIYCYHHDEAHSILES-YEKEEELKEHLSHCIQSLKKIYMQEGKPNL-LDMGSLMI 238

  Fly   200 VPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQEITQYLIHLQN--- 261
            .|||||.:|.|||.::...|.|:..||:.|.::...::....:||.....:::.  |.:.:|   
Human   239 KPIQRVMKYPLLLCELRNSTPPSHPDYRALDDAFAAVKDINVNINELKRRKDLV--LKYKKNDED 301

  Fly   262 -SLVNRTP-----NIVKPSRRVIKEGVLQKITHKGTEIK------------------RYCVLMSD 302
             ||.::..     :|.|.|:||...  |:.:|...:::|                  |.||  .:
Human   302 ESLKDKLSKLNIHSISKKSKRVTNH--LKILTRGESQVKDNTFNREEKLFRALEKTVRLCV--KN 362

  Fly   303 IFMYCKMIKERAP----------------------NTVVENSLECCCIF----------PLKKCK 335
            |.:..:.|::..|                      :..:.|:|..|..|          ||.  .
Human   363 ISLCLQHIQDAMPLALQSVMDLQEISYNKDDEMDYSETLSNALNSCHDFASHLQRLILTPLS--A 425

  Fly   336 VYEMLPGNFKLTCQSDGIIFGSGDVQLSRTWVGFIRDAIDLHVQCRKTLRKDSSKRTPIRKKDMK 400
            :..:.||..||                       |:...|..:.|...|::.:.:.:.:.||:.:
Human   426 LLSLFPGPHKL-----------------------IQKRYDKLLDCNSYLQRSTGEESDLAKKEYE 467

  Fly   401 KFGADYV-----LSPNKRK------CEYDTVFRNKNR----------------STDSE------E 432
            ...|..|     .:...||      |.:.|:.|:...                |:.||      |
Human   468 ALNAQLVEELQAFNQAARKILLNCLCSFITLLRDLMLVAQQAYSTLVPMPLLVSSISEIQNQVLE 532

  Fly   433 ETEDSACFSRKRKVASGILRAPNGNPMGKASSSSSSSVSMKRVAPPPPAPPPPPAVQMRHQPG-- 495
            |.::..|.  |...|:.|.|                .:|.::..|....|      :|.||..  
Human   533 EIQNLNCV--KENSATFIER----------------KLSFEKKKPVQILP------EMPHQTDIH 573

  Fly   496 RPGELATASKENRISKLYK-------------KIAAGDKVANVRGILKRSNVPAPNNDHDPSYGF 547
            |...|:|.|.|    :||:             .:..||.||.:             ...|| .|.
Human   574 RSKLLSTYSAE----ELYQAKRKCNATQEYDINLLEGDLVAVI-------------EQKDP-LGS 620

  Fly   548 ASRY----SDSKSYFRAHNVDNTIPTFVKREDLFNGDNMFPVHLKSHEEICTPPQKKRVKFDDTL 608
            .||:    .:.|.|..:..:....|..:::.|   .:|.|          |          ||..
Human   621 TSRWLVDTGNVKGYVYSSFLKPYNPAKMQKVD---AENRF----------C----------DDDF 662

  Fly   609 DAVSPVLVEKPFAFS---------SESSSALKPT 633
            :.:|..:..:|.:.|         .:|||:|..|
Human   663 ENISLFVSSRPASDSVTGTSESSIGDSSSSLSGT 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:279015 51/189 (27%)
PH-like 269..>311 CDD:302622 12/59 (20%)
PH 277..374 CDD:278594 21/146 (14%)
ARHGEF38NP_001229658.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..72 6/14 (43%)
RhoGEF 98..284 CDD:279015 52/190 (27%)
BAR_DNMBP 336..522 CDD:153273 30/212 (14%)
SH3 586..642 CDD:302595 13/69 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..694 5/20 (25%)
SH3_DNMBP_C2 717..773 CDD:213017
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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