Protein Alignment RhoGEF4 and arhgef39

DIOPT Version :10

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_001007342.2
• Gene: arhgef39 / 492469
• ZFINID: ZDB-GENE-041114-28
• Length: 427
• Species: Danio rerio
• Alignment Length: 452
• Identity: 127/452 - (28%)
• Similarity: 204/452 - (45%)
• Gaps: 63/452 - (13%)

  Fly    51 SNNSSPIGSPNPDAGKRLGFRRQ--------AIQEIISSEKSYLEQLELLMNFFVRPLKEQAIID 107
            |.:.||:   :|.:|:.:..:|:        ..:|:|.||:.|.:||||::.:||..||.:..:.
Zfish     2 SFSPSPL---SPMSGRSIQEQRERWERKRSRTAREMIQSEQRYCQQLELVVTYFVEILKAKGTLR 63

  Fly   108 CSNHTLLFGQIEMIHNLNGEFLRELEANMENVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLIS 172
            ......:|..|:.||.:|...|..||  |......|.:.....:||:.|..:.:.|..::...:.
Zfish    64 QDIRESIFSSIKSIHLINQTLLAHLE--MGRFGIGFEEFCTHLQLYNTYIDNIQTAKKVLMVQVK 126

  Fly   173 KNPVFRKFLEQTESRPEV-QRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEI 236
            |:..||:|.:..|||||. |:||..|:.:|:||:.:||..|..:...|.|.:.:::.|.::||.|
Zfish   127 KSKAFRRFKKLQESRPEFSQQKLEDLLELPLQRIQQYKHFLRDLTENTGPDNPEFQQLSKAVKAI 191

  Fly   237 EATASHINTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKGTEIK-RYCVLM 300
            ...|..|.......|....|..:|..|..|...|:.|.|..|:||.|:.:..||||.| :...|.
Zfish   192 SEVAQRIQDNARSHENHLQLRRVQKQLKGRKTRILTPGRWYIREGWLKTVPPKGTEAKPKMFYLF 256

  Fly   301 SDIFMYCKMIKERAPNTVVENSLECCCIFPLKKCKVYEMLPGNFKLTCQSDGII---FGSGDVQL 362
            |||.:..|......|..  .:...|..::|||:|.|.::    |..|....|:|   |....:.|
Zfish   257 SDILLQAKPCSPMHPTN--GDKFTCQRVYPLKECTVDKV----FGHTKSQGGLISLTFARAKLLL 315

  Fly   363 SRTWVGFIRDAIDLH------------VQCRKTL--RKDSSKRTPIRKKDMKKFGADYVLSPNKR 413
            ...      |.:|::            ::.|.|:  |:|...|||||.....:...:   |.|.|
Zfish   316 MSD------DQVDINDWYRSLCLTIGQLKSRNTVVHRRDELCRTPIRSDADDQSSTE---SQNTR 371

  Fly   414 KCEY-----DTVFRNKNRSTDSEEETEDSACFSRKRKVASGILRAPNGNPM-GKASSSSSSS 469
            ..:.     |.|....:||..|.||:..||  :::||        |:..|. |::..||.||
Zfish   372 GTKRAMMLDDEVREESSRSLSSTEESSRSA--TKRRK--------PDQTPADGRSQESSGSS 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:459876	53/170 (31%)
		PH-like	269..>311	CDD:473070	17/42 (40%)
		PH	277..374	CDD:459697	28/100 (28%)
arhgef39	NP_001007342.2	RhoGEF	31..198	CDD:459876	53/168 (32%)
		PH-like	203..>291	CDD:473070	28/89 (31%)