DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and ARHGEF35

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_001003702.2	Gene:	ARHGEF35 / 445328	HGNCID:	33846	Length:	484	Species:	Homo sapiens

Alignment Length:	99	Identity:	25/99 - (25%)
Similarity:	39/99 - (39%)	Gaps:	26/99 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DSNNSSPIGSP--------NPDAGKRLGFRRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAII 106
            |::..:...||        |.:.|...|..||. :|:.|.|..  |...||....|:.|:||...
Human   175 DNSGQTRYYSPCEEHPAETNQNEGAESGTIRQG-EELPSEELQ--ESQGLLHPQEVQVLEEQGQQ 236

  Fly   107 D-------------CSNHTLLFGQIEMIHNLNGE 127
            :             |::.  |.|:.:||..:|.|
Human   237 EAGFRGEGTLREDVCADG--LLGEEQMIEQVNDE 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	17/67 (25%)
		PH-like	269..>311	CDD:302622
		PH	277..374	CDD:278594
ARHGEF35	NP_001003702.2	ARHGEF5_35	1..478	CDD:317795	25/99 (25%)
ARHGEF35	NP_001003702.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..418		25/99 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900