DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and PLEKHG7

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_001364258.1	Gene:	PLEKHG7 / 440107	HGNCID:	33829	Length:	691	Species:	Homo sapiens

Alignment Length:	405	Identity:	80/405 - (19%)
Similarity:	158/405 - (39%)	Gaps:	109/405 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RRQAIQEIISSEKSY-LEQLELLMNFFVRPLK----EQAIIDCSNHTLLFGQIEMIHNLNGEFLR 130
            :::|:.|:.:||.:| |:.|.:|...|:..|:    .:.::|. :...||..:|.:...:..|:.
Human   289 QQEAVWELFTSECTYFLDHLLVLKMIFMNTLRYLQTHEYLLDV-DLWRLFANLEELTQTSLGFVN 352

  Fly   131 ELEANMENVAHA--------FLK-MAPFFK-----LYSVYAFDYRGALFIIQDLISKNP--VFRK 179
            .|...:::...|        |:. :..:|:     .:..|..:|..|:|.::.|..::.  ::.|
Human   353 SLFGIIKDYVDASEISSSLDFISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESLRQRDDFGIYLK 417

  Fly   180 FLEQTESRPEVQRKLN--SLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKE-IEATAS 241
            :.||.|.    .|:|:  .|::.|:||:.||.|||:.:  :....|:..|::..|:|| :|.:..
Human   418 WCEQNEQ----CRRLHVPELLVAPLQRLTRYPLLLKNI--WKRSMDSAEKIMIYSIKEKVEKSIR 476

  Fly   242 HINTCVEEQEITQYLIHLQNSLV-----------------------NRTPNIVKP-SRRVIKEGV 282
            .:...|:..:..|...:||..:|                       :...||:.| ||.::.||.
Human   477 DLEGKVKWLDNFQKFRYLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGK 541

  Fly   283 LQKITHKGTEIKRYCVLMSDIFMYCK--------------------------MIKERAPNTVVEN 321
            | .:......:..|..|.:|..:..|                          :|||....||::.
Human   542 L-TLAESTRFLDVYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQ 605

  Fly   322 SLEC------------CCIFPLKKCKV------YEMLPGNFKLTCQSDGIIFGSGDVQLSRTWVG 368
            .:..            ..:|.|:...:      |......|.|..|::.|         .:||:.
Human   606 PIPLDRLVVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENI---------KKTWMA 661

  Fly   369 FIRDAIDLHVQCRKT 383
            .|..||....:.::|
Human   662 QITTAISCFTKSQET 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	45/193 (23%)
		PH-like	269..>311	CDD:302622	12/68 (18%)
		PH	277..374	CDD:278594	22/140 (16%)
PLEKHG7	NP_001364258.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		DUF4675	2..178	CDD:406211
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..140
		RhoGEF	292..476	CDD:214619	45/190 (24%)
		PH_PLEKHG7	535..663	CDD:270065	21/137 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810