DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and trio

DIOPT Version :10

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster


Alignment Length:664 Identity:144/664 - (21%)
Similarity:236/664 - (35%) Gaps:168/664 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 SFSRELRQVL---QERNLLTAKSRRKVCSMLDSNNSSP-----IGSPNPD-----AGKRLGFRRQ 73
            |:..:|.:.|   |::.||.:.....:.|.....:|.|     :.|.|.:     ..||...||:
  Fly  1220 SYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARRK 1284

  Fly    74 --AIQEIISSEKSYLEQLELLMNFFVRPLK-----EQAIIDCSNHTLLFGQIEMIHNLNGE-FLR 130
              .:.|::.:|::|:..|...:..|:...:     ..|:|  ....::||.|:.||:.:.: |||
  Fly  1285 EFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALI--GQEDVIFGNIKEIHHFHQKIFLR 1347

  Fly   131 EL---EANMENVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFR---KFLEQTESRPE 189
            ||   |...|:|.|.|:..|..|.:|..|..:         ...|.|.:.:   .|.|:.:.|.|
  Fly  1348 ELEKYETMPEDVGHCFVTWASKFDMYVHYCKN---------KPTSNNLLVQHGGSFFEELQRRLE 1403

  Fly   190 VQRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQEITQ 254
            |...|.:.:|.|:||:.:|:|||:.:|   |..:..:..:||.::.:.......|..        
  Fly  1404 VDHPLPAYLIKPVQRITKYQLLLKDLL---SCCEESHGEIKEGLEVMLNVPKKANDA-------- 1457

  Fly   255 YLIHLQNSLVNRTPNIVKPSRRVIKEGVLQ-----KITHKGTEIKRYCVLMSDIFMYCKMIKERA 314
              :||  ||:......|.....|:.:...|     :|..||.|  |...|.....::.|.:||  
  Fly  1458 --MHL--SLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRE--RRVFLFELYLLFAKEVKE-- 1514

  Fly   315 PNTVVENSLECCCIFPLKKCKVYEMLPGNFKLTCQSDGII-FGSGDVQLSRTWVG---FIRDAID 375
             :.||:...:.                   ||.....||. ...||......|.|   .:.|   
  Fly  1515 -SNVVKYQFKS-------------------KLMTTDMGITEHIEGDETKFAVWTGRSPMLSD--- 1556

  Fly   376 LHVQCRKTLRKDSSKRTPIRKKDMKK------FGADYVLSPNKRKCEYDTVFRNKNRSTDSEEET 434
                ||..|:..|.:...|..|.:::      |....:..| |...::....:..:|..| |:.|
  Fly  1557 ----CRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLP-KSPAKHSGSSQRSSRDLD-EQLT 1615

  Fly   435 EDSACFSRKRKVASGILRAPNGNPMGK------------ASSSSSSSVS----MKRVAPPPPAPP 483
            |:...........|| ....:.|.:|.            .|.|:..|||    ::.|.||....|
  Fly  1616 ENDHDRCSLASFGSG-NTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEP 1679

  Fly   484 PPPAVQMRHQPGRPGELATASKENRISKLYKKIAAGDKVANVRGILKRSNVPAPNNDHDPSYGFA 548
            ....|::..|                         .|..|...|::..|.:..|...|....|.|
  Fly  1680 DFCLVRLNPQ-------------------------HDDAAVQEGLVPVSVLKPPPGSHKHGSGTA 1719

  Fly   549 --------SRYSDSKSYFRAHNVDNTIPTFVKREDLFNGDNMFPVHLKSHEEICTPPQKKRVKFD 605
                    |:.||.:........| .:.:..||.. |:|.|..|  |.:.:....||..|     
  Fly  1720 ANAASSAGSQKSDMQDQSNRSKAD-ALSSSTKRRG-FSGRNWLP--LMNRKGTDKPPSSK----- 1775

  Fly   606 DTLDAVSPVLVEKP 619
                    .||:||
  Fly  1776 --------PLVKKP 1781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:459876 46/181 (25%)
PH-like 269..>311 CDD:473070 10/46 (22%)
PH 277..374 CDD:459697 22/105 (21%)
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544 1/5 (20%)
RhoGEF 1287..1455 CDD:459876 46/181 (25%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 30/152 (20%)
SH3_Kalirin_1 1643..1707 CDD:212786 15/88 (17%)
RhoGEF 1945..2121 CDD:459876
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Blue background indicates that the domain is not in the aligned region.

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