DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and CG42674

DIOPT Version :9

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_649182.4 Gene:CG42674 / 40205 FlyBaseID:FBgn0261556 Length:1661 Species:Drosophila melanogaster


Alignment Length:699 Identity:121/699 - (17%)
Similarity:232/699 - (33%) Gaps:262/699 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 KVCSMLDS--NNSSP-----IGSPNPDAGKRLGFR-----------------------RQAIQEI 78
            ::|.:|:|  .|..|     :...:||....|.:.                       :.||.|:
  Fly   967 QLCELLNSYAKNGVPQRPDSMSFDHPDLVNSLAYLQYMHKSWRDFVNSDSMSESEVKIQTAIWEL 1031

  Fly    79 ISSEKSYLEQLELLMNFF---VRPLKEQAIIDCSNHTLLFGQIEMIHNLNGEFLRELEANME--- 137
            :::|..|:..|:.:.:.|   :..::|:.::...:...||..:..:          .|||::   
  Fly  1032 VTTEVYYIHALQTVTDLFLACLEAVQEEGLLIDVDQARLFSNVRAV----------CEANIKFWT 1086

  Fly   138 -----NVAHA---------------FLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLE 182
                 .|||:               ||..|..|..|.:|..:.....|..::|...|.:|..:|.
  Fly  1087 LWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLA 1151

  Fly   183 QTESRPEVQR-KLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEA-------- 238
            ..||:....| :|..:::.|:||:.:|.|||..:..:.|           .|:||||        
  Fly  1152 WCESQKMCNRLRLADIVVRPMQRLTKYSLLLAAIKKHMS-----------DVEEIEAIDVMMHSV 1205

  Fly   239 ------TASHINTCVEEQEITQYLIHLQNSLVNRTPN-----IVKPS------------------ 274
                  ..:|:....|.:.:...::.:::..|..|.|     ::|.:                  
  Fly  1206 ENFVGSVNNHLTMRQENERLKGVMVRIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCPAYHV 1270

  Fly   275 RRVIKEGVLQKITHK------GTEIKRYCVLMSDIFMYCKMIKER-------------------- 313
            |.:..||     .||      .:::  :|.|::|:.:.||.|.:|                    
  Fly  1271 RHLFMEG-----DHKFKDNLGKSDV--HCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIVQ 1328

  Fly   314 -APNTVVENSLECCCIFPLKKCKVYEMLPGNFKLTCQSDGIIFGSGDVQLSRTWVGFIRDAIDLH 377
             |||    |:|.|..:      ..:::....|.|.|..            ::.|...:..|..::
  Fly  1329 LAPN----NTLNCVYL------NEFQVATTAFTLQCTE------------AKNWYDALWRAKTIY 1371

  Fly   378 VQCRK----------TLRKDSSKR-------------TPIRKKDMKKFGADYVLSPNKRKCEYDT 419
            .:.::          |:....|.|             ..:||..|......:|.|.|  .....:
  Fly  1372 QRLKRGGGGGGSGSGTVGGGDSFRFGGSATSGGTADSLGVRKSPMNSSICSHVSSAN--NSHSGS 1434

  Fly   420 VFRNKNRS-------TDSEEETEDSACFS--------RKRKVASGILRAPNG--NPMGKASSSSS 467
            |..|.:|:       |:|....|.|:..:        .|:::.||:.:...|  ..||..|:::.
  Fly  1435 VEWNDSRNISVDFEKTNSVSSDEGSSIMTGNHGVNLKGKQQLISGLHKTKMGIIGQMGSKSANTL 1499

  Fly   468 S----------------------------------------SVSMKRVAPPPPAPPPPPAVQMRH 492
            |                                        |.|.:.::.|||:|...|.     
  Fly  1500 SVQPMNHLGQSLPNLNMHHSHTNNTLLVPGSTTSHSGNMLLSPSHRGISYPPPSPTRVPL----- 1559

  Fly   493 QPGRPGELATASKENRISKLYKKIAAGDKVANVRGILKRSNVPAPNNDH 541
               |.|...:.|.:|...:..:.|.:.:.: |...|......|:|.:.:
  Fly  1560 ---RRGMAFSTSTKNPPLRKTRNITSQNSI-NWHQIPATPTPPSPRSQY 1604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:279015 45/210 (21%)
PH-like 269..>311 CDD:302622 12/70 (17%)
PH 277..374 CDD:278594 21/123 (17%)
CG42674NP_649182.4 RhoGEF 1027..1213 CDD:279015 44/206 (21%)
PH_PLEKHG5_G6 1271..1366 CDD:270064 22/123 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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