DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and Exn

DIOPT Version :9

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster


Alignment Length:389 Identity:83/389 - (21%)
Similarity:154/389 - (39%) Gaps:92/389 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 TPRQKGYGNGFIHSPQTPLSFSRE-LRQVLQERNLLTAKSRRKVCSMLDSNNSS----------- 55
            |..:.|.|:.....|.:  .||.| |.|      :.:|.....:...|:::.||           
  Fly  1470 TGNEAGLGDELSSEPHS--LFSNEPLYQ------MYSAAKLESITRDLEAHGSSDGYEEIGLQAK 1526

  Fly    56 ----PIGSPNPDAGK--------------------------RLGFRRQAIQ----EIISSEKSYL 86
                |:..|.|.|.:                          .|..|.:::|    |||:||.|||
  Fly  1527 AKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYL 1591

  Fly    87 EQLELLMNFFV--RPLKEQAIIDCSNHTLLFGQIEMIHNLNGEFLRELEANMEN------VAHAF 143
            :.|.||...|:  ....:.:::...:...||..|..:|..:...|.||||..::      ::...
  Fly  1592 KSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCI 1656

  Fly   144 LKMAP-FFKLYSVYAFDYRGALFIIQDLISKNP---VFRKFLEQTESRPE-VQRKLNSLMIVPIQ 203
            .::|. .|.:|..:. :::|.:......:.::.   .|::.||:.|:.|. ....|:|.:::|:|
  Fly  1657 YEIAERHFHVYVAFC-EHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQ 1720

  Fly   204 RVPRYKLLLEQVLLYTSPAD-ADYK-------LLKESVKEIEATASHINTCVEEQEITQYL---I 257
            |:.|..||::.|....||.: .:|:       |:::.|.:....|:......|.:.|.:.|   .
  Fly  1721 RITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPS 1785

  Fly   258 HLQNSLVN--RTPNIVKPSRRVIKEGVLQKITHKG-----------TEIKRYCVLMSDIFMYCK 308
            |::...:.  ..|......|.::|.|.|..:..:|           |:|..|..|.||:.:.||
  Fly  1786 HVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCK 1849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:279015 46/194 (24%)
PH-like 269..>311 CDD:302622 13/51 (25%)
PH 277..374 CDD:278594 12/43 (28%)
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 44/182 (24%)
PH_ephexin 1805..1931 CDD:269929 13/45 (29%)
SH3_ephexin1_like 1944..1998 CDD:212727
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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