Protein Alignment RhoGEF4 and plekhf2

DIOPT Version :10

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_956538.1
• Gene: plekhf2 / 393214
• ZFINID: ZDB-GENE-040426-884
• Length: 247
• Species: Danio rerio
• Alignment Length: 315
• Identity: 54/315 - (17%)
• Similarity: 100/315 - (31%)
• Gaps: 130/315 - (41%)

  Fly   273 PSRRVIKEGVLQKITHKGTEIKRYCVLMSDIFMYCKMIKERAPNTVVENSLECCCIFPLKKCKVY 337
            |.|.:|.||||.|:..|..:.::: .|.:||.:|..::.::.......       |.||:...:.
Zfish    32 PGRVLIGEGVLTKLCRKRPKARQF-FLFNDILVYGNIVIQKKKYNKQH-------IIPLESVTID 88

  Fly   338 EMLPGNFKLTCQSDGIIFGSGDVQLSRTWVGFIRDAIDLHVQCRKTLRKDSSKRTPIRKKDMKKF 402
                     |.:.:|        :|...|:
Zfish    89 ---------TVEDEG--------ELRNGWL----------------------------------- 101

  Fly   403 GADYVLSPNKRKCEYDTVFRNKNRSTDSEEETEDSACFSRKRKVASGILRAPNGNPMGKASS--- 464
                :.:|.|....|            :...||.|...|...|..|.:|.....:|.|:.::
Zfish   102 ----IKTPTKSFAVY------------AATATEKSEWMSHINKCVSDLLEKSGKSPTGEHAAVWV 150

  Fly   465 -SSSSSVSMK----RVAPPPPAPPPPPAVQMRHQPGRPGEL-------------ATASKENRISK 511
             .|.::|.|:    :..|          |..||...:.|.:             :.:||..|:.:
Zfish   151 PDSEATVCMRCQKMKFTP----------VNRRHHCRKCGFVVCGPCSEKKFLLPSQSSKPVRVCE 205

  Fly   512 L-YKKIAAGDKVANVRGILKRSNVPAPNNDHDPSYGFASRYSDSKSYFRAHNVDN 565
            . ||:::.|            :.:| |.:|         .||...|.|.::|:.:
Zfish   206 FCYKQLSTG------------ATLP-PRSD---------SYSRQGSDFGSNNISD 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:459876
		PH-like	269..>311	CDD:473070	13/37 (35%)
		PH	277..374	CDD:459697	18/96 (19%)
plekhf2	NP_956538.1	PH_Phafin2-like	7..129	CDD:269927	27/172 (16%)
		FYVE_PKHF2	148..211	CDD:277294	13/72 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..247		9/48 (19%)