Protein Alignment RhoGEF4 and CG30440

DIOPT Version :10

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_610172.1
• Gene: CG30440 / 35496
• FlyBaseID: FBgn0050440
• Length: 1057
• Species: Drosophila melanogaster
• Alignment Length: 481
• Identity: 99/481 - (20%)
• Similarity: 198/481 - (41%)
• Gaps: 69/481 - (14%)

  Fly    71 RRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCS---NHTLLFGQIEMIHNL-NGEFLRE 131
            |...::|:..:||.|:.::..::..:...||.......|   ...:|||.:..|::. |..||::
  Fly   619 RGHILKELFETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFLKD 683

  Fly   132 LE---ANMENVAHAFLKMA-PFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQTESRPEVQR 192
            ||   :..|.||..|:|.. .|::|||.|..:.:.:..:.:.|:..:..|:      |.:..:..
  Fly   684 LENCISVTERVALCFVKRRDKFYQLYSFYCQNIQRSEKLRETLVDTHMFFK------ECQIGLGH 742

  Fly   193 K--LNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQEITQY 255
            |  |.:.::.|:||:.:|:|||:.:||:|. .|:....||.::..:......:|..:.:..||.:
  Fly   743 KLPLGAYLLKPVQRITKYQLLLKDLLLFTD-NDSCRNELKNALDCMLIVLKCVNDSMHQISITGF 806

  Fly   256 LIHLQNSLVNRTPNIVKPSRRV---IKEGVLQKITHKGTEIKRYCVLMSDIFMYCKMIKERAPNT 317
                ...|..:...:::.|.:|   .|:.:..::..|    :|:..|.....:.||...:...|
  Fly   807 ----SGDLAKQGELLMQDSFQVWIESKKDIRLRMKPK----RRHIFLYQKSLLLCKQTSKSGYN- 862

  Fly   318 VVENSLECCCIFPLKKCKVYEMLPGNFK-----LTCQSDGIIFGSGDVQLSRTWVGFIRDAIDLH 377
              ::|.:......:.:..:.|.:.|:.|     |..:.:.....:..:.:...||..|:..  |.
  Fly   863 --KSSYQFKSDVKMSQIGLTESVSGDAKRFEVWLKGRQEVYTLQASTIGVKEMWVAEIKRV--LF 923

  Fly   378 VQCRKTLRKDSSKRTPIRKKDM-KKFGADYVLSPNKRKCE------YDTVFRNKNRSTDSEEETE 435
            .|..| |:.|...|..||.:.: :|...:   :||...|.      ::....:.||:|:...|
  Fly   924 NQLEK-LKGDQIARYNIRHQSLWQKSSCE---APNITHCSLRRTECFELPLNDSNRNTNIRSE-- 982

  Fly   436 DSACFSRKRKVASGILRAPNGNPMGKASSSSS--SSVSMKRVAPPPPAPPPPPAVQMRHQPGRPG 498
             ..|.|.:     .|:..|:.....:.:|.||  |.:.......|          .:..:.|:|.
  Fly   983 -KTCLSDQ-----NIVNGPSVQDQHEKNSWSSDCSDIDEDETINP----------ILMQKTGQPK 1031

  Fly   499 ELATASKENRISKLYKKIAAGDKVAN 524
            .|...|..:::....|.|.:...|.|
  Fly  1032 LLWNRSSSHQVFIKSKYILSRKTVNN 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:459876	44/179 (25%)
		PH-like	269..>311	CDD:473070	8/44 (18%)
		PH	277..374	CDD:459697	16/104 (15%)
CG30440	NP_610172.1	RhoGEF	622..796	CDD:214619	44/180 (24%)
		PH-like	802..925	CDD:473070	21/135 (16%)