Protein Alignment RhoGEF4 and Arhgef2

DIOPT Version :9

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_006232705.1
• Gene: Arhgef2 / 310635
• RGDID: 1304659
• Length: 1180
• Species: Rattus norvegicus
• Alignment Length: 441
• Identity: 81/441 - (18%)
• Similarity: 172/441 - (39%)
• Gaps: 111/441 - (25%)

  Fly    18 QTPLSFSRELRQVL-QERNLLTAKSRR-KVCSMLDSN---------------------------- 52
            ::||.    |||:| |..:.|..::|. .|.|::|..
  Rat   357 ESPLG----LRQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELMSDFEMDEKDFEADSWSLAV 417

  Fly    53 NSSPIGSPNPDAGKRLGFRRQAIQEIISSEKSYLEQLELLMNFF---------VRPLKEQAIIDC 108
            :||.:.....:..|    ::..|.|:|.:|..::..|:::...|         :.|...|.:..|
  Rat   418 DSSFLQQHKKEVMK----KQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELQMEPEVVQGLFPC 478

  Fly   109 SN-----HTLLFGQI---------------EMIHNLNGEFLRELE-ANMENVAHAFLKMAPFFKL 152
            .:     ||....|:               .:||.|....:.:.. :|.|.:.          |.
  Rat   479 VDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGSNAEQMR----------KT 533

  Fly   153 YSVYAFDYRGALFIIQDLISKNPVFRKFL-EQTESRPEVQRKLNSLMIVPIQRVPRYKLLLEQVL 216
            ||.:...:..||.:.::|.:::..|::|: :.|.|....:..:...:::..||:.:|.:|:.::|
  Rat   534 YSEFCSRHTKALKLYKELYARDKRFQQFIRKMTRSAVLKRHGVQECILLVTQRITKYPVLINRIL 598

  Fly   217 LYTSPADADYKLLKESVKEIEATASHINTCVEEQEITQYLIHLQNSLVNRTPNIVKPS------- 274
            ..:...:.:|:.|..::..::...|:::..|.|.|....|..:.|.:..|....|...
  Rat   599 QNSHGIEEEYQDLAAALGLVKELLSNVDQDVHELEKEARLQEIYNRMDPRAQTPVPGKGPFGRDE 663

  Fly   275 ---RRVIKEGVLQKITHKGTEIKRYCVLMSDIFMYCKMIKERAPNTVVENSLECCCIFPLKKCKV 336
               |::|.:|.|...|..|.......:||:|:.::   ::|: ....:..||:...:..|:...|
  Rat   664 LLRRKLIHDGCLLWKTATGRFKDVLLLLMTDVLVF---LQEK-DQKYIFTSLDKPSVVSLQNLIV 724

  Fly   337 YEMLPGNFKLTCQSDGI-IFGSGDVQL------SR----TWVGFIRDAIDL 376
            .:       :..|:.|: :..||..::      ||    ||:..|:.::.|
  Rat   725 RD-------IANQAKGMFLISSGPPEMYEVHAASRDDRTTWIRVIQQSVRL 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	35/200 (18%)
		PH-like	269..>311	CDD:302622	10/51 (20%)
		PH	277..374	CDD:278594	22/107 (21%)
Arhgef2	XP_006232705.1	C1_ARHGEF2	230..290	CDD:410427
		RhoGEF	432..626	CDD:238091	35/203 (17%)
		PH_ARHGEF2	666..781	CDD:275428	24/114 (21%)
		SMC_prok_B	<898..>1057	CDD:274008

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810