DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and Arhgef26

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	XP_227201.4	Gene:	Arhgef26 / 310460	RGDID:	1562559	Length:	869	Species:	Rattus norvegicus

Alignment Length:	319	Identity:	81/319 - (25%)
Similarity:	135/319 - (42%)	Gaps:	54/319 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QERNLLTAKSRRKVCSMLDSNNSSPIGSPNPDAGKRLGF----------RRQAIQEIISSEKSYL 86
            :|:.::..|..|...|.|             .|.||.|.          |::||.|:||||.|||
  Rat   402 EEKIVIHHKPLRSTWSQL-------------SAVKRNGLSQTVSQEERKRQEAIFEVISSEHSYL 453

  Fly    87 EQLELLMNFFVRPLKEQAIIDCSNHT---LLFGQIEMIHNLNGEFLRELEANMEN---------- 138
            ..||:|:..| :..||  :.|....|   .||..|..:...:.:|..||||..:|
  Rat   454 LSLEILIRMF-KDSKE--LTDTMTKTERHHLFSNITDVWEASKKFFTELEARHQNNIFIEDISDI 515

  Fly   139 -VAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQTESRPEVQR-KLNSLMIVP 201
             ..|......|:.|..:...:..|    .:|.|::.||.|::.|.:.||..:.:. .:.|.:|:|
  Rat   516 VEKHTASTFDPYVKYCTNEVYQQR----TLQKLLTTNPSFKEVLSRIESHEDCRNLPMISFLILP 576

  Fly   202 IQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQEITQ--YLIHLQNSLV 264
            :|||.|..||::.:...|......|::.|.::||:.......|....:.|.|:  |.|:.|....
  Rat   577 MQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFK 641

  Fly   265 NRTPNIVKPSRRVIKEGVLQK-------ITHKGTEIKRYCVLMSDIFMYCKMIKERAPN 316
            .:...:|..||.::|.|.|..       .:.:.::.:.|..|.:|:.:..|...|.:.|
  Rat   642 IKPFPLVSSSRWLVKRGELTAYVEDTVLFSKRMSKQQVYFFLFNDVLIITKKKSEESYN 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	53/184 (29%)
		PH-like	269..>311	CDD:302622	10/48 (21%)
		PH	277..374	CDD:278594	9/47 (19%)
Arhgef26	XP_227201.4	TDA11	140..>348	CDD:293689
		RhoGEF	441..620	CDD:279015	53/185 (29%)
		PH_ephexin	641..779	CDD:269929	12/60 (20%)
		SH3_ARHGEF16_26	791..845	CDD:212871
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810