DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and Fgd3

DIOPT Version :10

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_056574.2 Gene:Fgd3 / 30938 MGIID:1353657 Length:733 Species:Mus musculus


Alignment Length:496 Identity:118/496 - (23%)
Similarity:201/496 - (40%) Gaps:123/496 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 QEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQIEMIHNLNGEFL---------RE 131
            ||::.:|::|:::|.||...|...|.| |.|.....|.:|..|..|:..:|:||         .|
Mouse   159 QELLHTEEAYVKRLHLLDQVFCTKLTE-AGIPLEVTTGIFSNISSIYRFHGQFLLPELQKRITEE 222

  Fly   132 LEANMENVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQTESRPEV--QRKL 194
            .:.| ..:.....|:|||.|:|..|..::..|:.::.....::|.|:..: .|..:.||  ...|
Mouse   223 WDTN-PRLGDILQKLAPFLKMYGEYVKNFDRAMGLVSTWTQRSPQFKDVI-HTIQKQEVCGNLTL 285

  Fly   195 NSLMIVPIQRVPRYKLLLEQVLLYTSPADA-DYKLLKESVKEIEATASHINTCVEEQEITQYLIH 258
            ...|:.|:||||||:|||:. .|...|.|| |.|..:.|::.|...|.|.|..:.:.|....|:.
Mouse   286 QHHMLEPVQRVPRYELLLKD-YLKRLPRDAPDRKDAERSLELISTAADHSNAAIRKMEKMHKLLE 349

  Fly   259 LQNSLVNRTPNIVKPSRRVIKEGVLQKITHK-GTEIKRYCVLMSDIFMYC--------------- 307
            :...| ....:||.|:..:||||.:||::.| ||...|:..|.:::.:||               
Mouse   350 VYEQL-GGEEDIVNPANELIKEGSIQKLSAKNGTTQDRHLFLFNNVMLYCVPKLRLMGQKLSVRE 413

  Fly   308 KM-IKERAPNTVVENSLECCCIFPLKKCKVYEMLPGNFKLTCQSDGIIFGSGDVQLSRTWVGFIR 371
            || |.:.....:|:.:..|..|...:|        .:.:|..:::         :..:.|:..|:
Mouse   414 KMDISDLQVQDIVKPNAACTFIITGRK--------RSLELQTRTE---------EEKKEWIQVIQ 461

  Fly   372 DAIDLHVQCRKTLR-------------------------------KDSSKRTP---IRK------ 396
            ..::.|.|..:|.|                               .||:..||   .||      
Mouse   462 ATVEKHKQKSETFRAFGGACSQDEEPTLSPDQPVMSTSSVEPAGVADSNGGTPGIESRKSSSKTR 526

  Fly   397 KDMKKFG----ADYVLSPNKRK----------CEYDTVFRNKNRSTDSEEETEDSACFSRKRKVA 447
            :|.:|.|    .:...|..||:          |...:.|:.:|    |::......||..:    
Mouse   527 RDKEKPGCKSCGETFNSITKRRYRCKLCGEVICRKCSEFKAEN----SKQSRVCRECFLEE---- 583

  Fly   448 SGILRAPNGNPMGKASSSSSSSVSMKRVAPPPPAPPPPPAV 488
                      |:...|.||.:...:|:.|..||:..|.|::
Mouse   584 ----------PLVPPSPSSETPTELKQNAEKPPSVDPRPSL 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:459876 56/179 (31%)
PH-like 269..>311 CDD:473070 18/58 (31%)
PH 277..374 CDD:459697 23/113 (20%)
Fgd3NP_056574.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..134
RhoGEF 157..335 CDD:459876 56/179 (31%)
PH-like 367..474 CDD:473070 25/123 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..535 9/53 (17%)
FYVE_FGD3 527..580 CDD:277279 10/56 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 586..612 8/25 (32%)
PH2_FGD1-4 606..710 CDD:270056 3/9 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 712..733
Blue background indicates that the domain is not in the aligned region.

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