Protein Alignment RhoGEF4 and Plekhf1

DIOPT Version :10

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_001013166.1
• Gene: Plekhf1 / 308543
• RGDID: 1310544
• Length: 279
• Species: Rattus norvegicus
• Alignment Length: 267
• Identity: 48/267 - (17%)
• Similarity: 84/267 - (31%)
• Gaps: 90/267 - (33%)

  Fly   244 NTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKGTEIKRYCVLMSDIFMYCK 308
            ||.:..|.|..    ::|........:..|.|.::.||||.|...|..: .|...|.:||.:|..
  Rat     7 NTEINSQRIAA----VENCFGASGQPLALPGRVLLGEGVLTKECRKKAK-PRIFFLFNDILVYGS 66

  Fly   309 MI----KERAPNTVVENSLECCCIFPLKKCKVYEMLP------GNFKLTCQSDGIIFGSGDVQLS 363
            ::    |.|:.:           |.||::..: |.||      ..:.:.......:..:......
  Rat    67 IVLSKRKYRSQH-----------IIPLEEVTL-EPLPETLQAKNRWMIKTAKKSFVVSAASTTER 119

  Fly   364 RTWVGFIRD-------------------------AIDLHVQCRKTLRKDSSKRTPIRK------- 396
            :.|:..|.:                         |.|:.::|.:|.....::|...||
  Rat   120 QEWISHIEECVRRQLLATGRQPTTEHAAPWIPDKATDICMRCTQTRFSALTRRHHCRKCGFVVCA 184

  Fly   397 --------------KDMKKFGADY-VLSPNKRKCEYDTVFR----------------NKNRSTDS 430
                          |.::.....| .|:..||:.|....||                :.....||
  Rat   185 ECSRERFLLPRLSPKPLRVCSLCYRELAAQKRREEAKERFRGSPGQLTHLGSTMCGASSGDDDDS 249

  Fly   431 EEETEDS 437
            :|:.|.|
  Rat   250 DEDREGS 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:459876	48/267 (18%)
		PH-like	269..>311	CDD:473070	13/45 (29%)
		PH	277..374	CDD:459697	21/131 (16%)
Plekhf1	NP_001013166.1	PH_Phafin2-like	7..129	CDD:269927	28/138 (20%)
		FYVE_PKHF1	148..211	CDD:277293	9/62 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..264		8/38 (21%)