Protein Alignment RhoGEF4 and ARHGEF16

DIOPT Version :9

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_016856538.1
• Gene: ARHGEF16 / 27237
• HGNCID: 15515
• Length: 726
• Species: Homo sapiens
• Alignment Length: 434
• Identity: 108/434 - (24%)
• Similarity: 176/434 - (40%)
• Gaps: 93/434 - (21%)

  Fly     5 RQKGYGNGFIHSPQTPLSFSRELRQVLQERNLLTAKSRRKVCSMLDSNNSSPIGSPNPDAG---- 65
            |::|:...|...||        |.|.:|||.|.|  |:.....:|| .:|||.|:...||.
Human   218 RKRGHKGSFKDDPQ--------LYQEIQERGLNT--SQESDDDILD-ESSSPEGTQKVDATIVVK 271

  Fly    66 ---------------KRLGF----------RRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAI 105
                           ..||.          |::|:.||::||.||...|.:|:..|::..:.:|.
Human   272 SYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRAT 336

  Fly   106 IDCSNHTLLFGQIEMIHNLNGEFLRELEAN------MENVA-----HAFLKMAPFFKLYSVYAFD 159
            :....|..||..|..:...:..|..:||..      :|:::     ||.....|:....|...:.
Human   337 VTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQ 401

  Fly   160 YRGALFIIQDLISKNPVFRKFLEQTESRPEV-QRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPAD 223
            .|    .:|.|||.|..||:.|.:.|.||.. ...:.|.:|:|:|||.|..||::.:.|.|....
Human   402 QR----TLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 462

  Fly   224 ADYKLLKESVKEIEATASHINTCVEEQEITQ--YLIH--LQNSLVNRTPNIVKPSRRVIKEGVL- 283
            ..||....::|.|.......|......|..:  |.:|  |..|.|...| ::..||.::|.|.|
Human   463 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLP-LISASRWLLKRGELF 526

  Fly   284 --------QKITHKGTEIKRYCVLMSDIFMYCKMIKERAPNTVVENSLECCCIFPLKKCKVYEM- 339
                    :||..:.|   .|..|.:|:.:..|  |:...:.:|::..:...| .::|.:..|:
Human   527 LVEETGLFRKIASRPT---CYLFLFNDVLVVTK--KKSEESYMVQDYAQMNHI-QVEKIEPSELP 585

  Fly   340 LPGN----------FKLTC--QSDG----IIFGSGDVQLSRTWV 367
            |||.          |::|.  .|:|    ::..|........|:
Human   586 LPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWI 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	50/181 (28%)
		PH-like	269..>311	CDD:302622	12/50 (24%)
		PH	277..374	CDD:278594	24/117 (21%)
ARHGEF16	XP_016856538.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810