Protein Alignment RhoGEF4 and Fgd2

DIOPT Version :10

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_036016509.1
• Gene: Fgd2 / 26382
• MGIID: 1347084
• Length: 673
• Species: Mus musculus
• Alignment Length: 331
• Identity: 83/331 - (25%)
• Similarity: 161/331 - (48%)
• Gaps: 55/331 - (16%)

  Fly    15 HSPQTPLSFSRE------LRQVLQE-------------RNLLTAKSRRKVCSMLDSNNSSPIGSP 60
            |||:..||.|.|      :::.|:.             :|.|::.:.|:.|        .|..||
Mouse    39 HSPEHQLSLSPEPWEAPPVKEALKSEFRPVSRTYLSSLKNKLSSGAWRRSC--------QPGVSP 95

  Fly    61 NPDAGKRLGFRRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQA---------IIDCSNHTLLFG 116
            .|:..:  ...::.::|::.:|::|:.:|.||...|.:.|..:|         ::     .|:|.
Mouse    96 GPETQE--PEEKRVVRELLETEQAYVARLHLLDQVFFQELLREAGRSKAFPEDVV-----KLIFS 153

  Fly   117 QIEMIHNLNGE-FLRELEANMEN------VAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKN 174
            .|..|:..:.: ||.||:..:::      :.....|:|||.|:||.|..::..|..::...:.|:
Mouse   154 NISSIYRFHAQFFLPELQRRVDDWAATPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWMDKS 218

  Fly   175 PVFRKFLEQTE-SRPEVQRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADA-DYKLLKESVKEIE 237
            ..|::.:.:.: |.......|...|:.|:||:|||:|||:: .:...||.| |.:..:.::..|.
Mouse   219 QPFQEVVTRIQCSEASSSLTLQHHMLEPVQRIPRYELLLKE-YVQKLPAQAPDLEDAQRALDMIF 282

  Fly   238 ATASHINTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKGTE-IKRYCVLMS 301
            :.|.|.|..:.|.|..|.|..:...| ....:||.||..:::||.:.||:.:.:: ::||.||.:
Mouse   283 SAAQHSNAAIAEMERLQGLWDVYQRL-GLEDDIVDPSNTLLREGPVLKISFRRSDPMERYLVLFN 346

  Fly   302 DIFMYC 307
            ::.:||
Mouse   347 NMLLYC 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:459876	47/187 (25%)
		PH-like	269..>311	CDD:473070	14/40 (35%)
		PH	277..374	CDD:459697	10/32 (31%)
Fgd2	XP_036016509.1	RhoGEF	105..289	CDD:238091	47/189 (25%)
		PH1_FGD2	321..428	CDD:275421	10/32 (31%)
		FYVE_FGD1_2_4	454..535	CDD:277280
		PH2_FGD1-4	556..658	CDD:270056