DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and rgf1

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_588116.1	Gene:	rgf1 / 2539580	PomBaseID:	SPCC645.07	Length:	1334	Species:	Schizosaccharomyces pombe

Alignment Length:	292	Identity:	72/292 - (24%)
Similarity:	128/292 - (43%)	Gaps:	54/292 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RRQAIQEIISSEKSYLEQLELLMNFFVRPL----------KEQAIIDCSNHTLLFGQIEMIHNLN 125
            |::.|.|:|.:|:.:::.||.|.:::::||          ||:.|     .|:....:| :..:|
pombe   622 RQEVICEVIYTERDFVKDLEYLRDYWIKPLWASSCIPERKKEKFI-----RTVFLNALE-VQAVN 680

  Fly   126 GEFLRELEAN------MENVAHAFLKMAPFF---------KLYSVYAFDYRGALFIIQDLISKNP 175
            .:....|...      ::|:|..||:..|.|         :||..|.|:...         |.||
pombe   681 SKLAEALTKRQNYKPIVDNIADIFLEHVPKFEPFIRYGAGQLYGKYEFEKEK---------SSNP 736

  Fly   176 VFRKFLEQTESRPEVQR-KLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEAT 239
            .|.||:...|...|.:: :||..:..|..|:.||.||||.||.||...:.|.:.:.:.:..:...
pombe   737 AFAKFVSDVERLKESRKLELNGYLTKPTTRLARYPLLLEAVLKYTDEGNPDKQDIPKVINIVRGF 801

  Fly   240 ASHINTCVEEQEITQYLIHLQNSLVNRTP-----NIVKPSRRVIKEGVLQKITHKGTEIKRYCVL 299
            .|.:|....:.|....|.||...||.:..     :::..:|::|.:|.|:|.:...|..:.
pombe   802 LSRLNVESGKAENKFNLFHLNQQLVFKPGEHYDLHLLDANRQLIFKGPLKKRSAGSTSSES---- 862

  Fly   300 MSDI--FMYCKMIKERAPNTVVENSLECCCIF 329
            .||:  |::...:....|.|:  |..|...:|
pombe   863 ASDVTLFLFDHALLIVKPKTI--NKRELLKVF 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	50/195 (26%)
		PH-like	269..>311	CDD:302622	9/43 (21%)
		PH	277..374	CDD:278594	13/55 (24%)
rgf1	NP_588116.1	ROM1	6..1320	CDD:227709	72/292 (25%)
		DEP_fRom2	416..497	CDD:239882
		RhoGEF	625..806	CDD:279015	50/195 (26%)
		PH_5	844..972	CDD:292048	13/55 (24%)
		CNH	1004..1290	CDD:279162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	63	1.000	Domainoid score	I2911
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47379
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.900