DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and rgf3

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_588115.1	Gene:	rgf3 / 2539437	PomBaseID:	SPCC645.06c	Length:	1275	Species:	Schizosaccharomyces pombe

Alignment Length:	300	Identity:	70/300 - (23%)
Similarity:	124/300 - (41%)	Gaps:	50/300 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 NSSPIGSPNPDAGKRLGFRRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQ--AIIDCSNHTL-- 113
            |.|.:.|......||...|:..|.|:|..|..|:..|..|...|...:.:|  ||:. ||...
pombe   448 NISSLNSLPSSLSKREIARQNNIHELICKESDYVADLNTLAELFRDGIVQQQDAIVP-SNRVADF 511

  Fly   114 ---LFGQIEMIHNLNGE------FLRE-LEANMENV--------AHA----FLKMAPFFKLY-SV 155
               :||.:|.|..|:..      .:|| |:..:.::        .||    ::..|..|.|. ..
pombe   512 IQSVFGNVESIRQLHSRLFLPQLIMRERLQGPVVSIIGDILLEWIHAAKSSYINYAKQFPLADET 576

  Fly   156 YAFDYRGALFIIQDLISKNPVFRKFLEQTESRPEVQR-KLNSLMIVPIQRVPRYKLLLEQVLLYT 219
            |..:           ..:|..|.::|....|.|..:| .....:..|.||:.||.|.|:.:|.:|
pombe   577 YKLE-----------CQRNTYFARWLAACRSDPRCRRLDFQHFLQRPTQRLQRYTLELDTILKHT 630

  Fly   220 SPADADYKLLKESVKEIEATASH----INTCVEE---QEITQYLIHLQNSLVNRTPNIVKPSRRV 277
            ..:..|::|:.::|||:.||...    |.|.:|.   ::::..|:...:..||.  .:..|.|..
pombe   631 EQSSWDFQLITQAVKELRATCEECDAVIATVLEANRIRDLSYQLLFKNHESVNL--ELRDPEREF 693

  Fly   278 IKEGVLQKITHKGTE-IKRYCVLMSDIFMYCKMIKERAPN 316
            ..||::|:.:....: :..:..|:.:..:..|..|::..|
pombe   694 FFEGIVQRRSDSRLDWLDIHLFLLDNYLIMAKARKDKRTN 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	49/201 (24%)
		PH-like	269..>311	CDD:302622	7/42 (17%)
		PH	277..374	CDD:278594	6/40 (15%)
rgf3	NP_588115.1	RhoGEF	470..656	CDD:279015	49/197 (25%)
		PH-like	695..850	CDD:302622	6/38 (16%)
		CNH	939..1236	CDD:279162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47379
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.770