Protein Alignment RhoGEF4 and Fgd4

DIOPT Version :9

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_038943909.1
• Gene: Fgd4 / 246174
• RGDID: 708357
• Length: 887
• Species: Rattus norvegicus
• Alignment Length: 466
• Identity: 109/466 - (23%)
• Similarity: 192/466 - (41%)
• Gaps: 106/466 - (22%)

  Fly    77 EIISSEKSYLEQLELLMNFFVRPLKEQA---IIDCSNHTLLFGQIEMIHNLNGEF-LRELEANME 137
            |::.:|::|:.:|.||...|...|.|:|   .........:|..|..|:..:.:| |.|||..|:
  Rat   334 ELLLTERAYVSRLNLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQ 398

  Fly   138 ------NVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQTESRPEVQRK--- 193
                  .:.....|:|||.|:|..|...:..|:.:::::..:.|.|:...|      |:|::
  Rat   399 EWETTPRIGDILQKLAPFLKMYGEYVKGFDNAVELVKNMTERVPQFKSVTE------EIQKQKIC 457

  Fly   194 ----LNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQEITQ 254
                |...|:.||||:|||::||:..|...||...|:...|:|::.|...|||.|:.:.:.|..:
  Rat   458 GSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPDAPDWNDAKKSLEIISTAASHSNSAIRKMENLK 522

  Fly   255 YLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKGTEI-KRYCVLMSDIFMYCKMIKERAPN-T 317
            .|:.:. .::....:||.||..:||||.:.|:..:.|.. :||..|.:::.:||      .|. :
  Rat   523 KLLEIY-EMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYC------VPRFS 580

  Fly   318 VVENSLECCCIFPLKKCKVYEM----LPGNFKLTCQSDGIIFGSGDVQLSRTWVGFIRDAIDLHV 378
            :|.:.........:...|:.|.    .|..|:::.:...:...:...|....|:..::::||...
  Rat   581 LVGSKFTVRTRVGIDGMKIVETHNEEYPHTFQVSGKERTLELQASSEQDKEEWIKALQESIDAFH 645

  Fly   379 QCRKTLRK---------------DSSKRTP--IRKKDM-------KKFGA--------------- 404
            |..:|.|.               :..||.|  ||..::       :.|.|
  Rat   646 QRHETFRNAIAKENDIPLEVSTAELGKRAPRWIRDNEVTMCMKCKESFNALTRRRHHCRACGHVV 710

  Fly   405 -----DYVLSPNKRKCEYDTVFRNK---------NRSTDSEEETEDSACFSRKRKVASGILRAPN 455
                 ||     |.:.|||....||         :...:|||         :||:   |||...:
  Rat   711 CWKCSDY-----KAQLEYDGGRLNKVCKDCYQIMSGFAESEE---------KKRR---GILEIES 758

  Fly   456 GNPMGKASSSS 466
            ....|.:...|
  Rat   759 AEVSGNSEVCS 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	53/183 (29%)
		PH-like	269..>311	CDD:302622	15/42 (36%)
		PH	277..374	CDD:278594	19/102 (19%)
Fgd4	XP_038943909.1	RhoGEF	328..512	CDD:238091	53/183 (29%)
		PH1_FDG4	544..637	CDD:275434	19/98 (19%)
		FYVE_FGD1_2_4	675..739	CDD:277280	13/68 (19%)
		PH2_FGD1-4	758..860	CDD:270056	2/12 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto98326
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X316
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910