DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and Arhgef9

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	XP_006528055.1	Gene:	Arhgef9 / 236915	MGIID:	2442233	Length:	523	Species:	Mus musculus

Alignment Length:	452	Identity:	88/452 - (19%)
Similarity:	170/452 - (37%)	Gaps:	82/452 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 PNPDA---GKRLGFRRQ----AIQEIISSEKSYLEQLELLMNFFVRPL-KEQAIIDCSNHTLLFG 116
            ||.|.   |:.|..|.|    .|.||:|:|:.|::.|:.:...:::.. |.:.:.......::||
Mouse    93 PNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFG 157

  Fly   117 QIEMIHNLNGEFLRELEANMEN-------VAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKN 174
            .||.|:.....|:|:||....|       :...||:....|.:||.|..::..|...:..|: |:
Mouse   158 NIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLM-KD 221

  Fly   175 PVFRKFLEQTESRPE-VQRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEA 238
            ..::.|.|......: :...::..::.|:|::.:|.|.|.::|.||:...:||:.:..::..:..
Mouse   222 SRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRN 286

  Fly   239 TASHINTCVEEQEITQYLIHLQNSLVN-RTPNIVKPSRRVIKEGVLQKITHK-GTEIKRYCVLMS 301
            ....||......|....:...|.|::: ...:|:..|..:|..|.:..|... |...:|...|..
Mouse   287 VTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFD 351

  Fly   302 DIFMYCK--MIKERAPNTVVENSLECCCIFPLKKCKVYEMLPGNFKLTCQSDGIIFGSGDVQLSR 364
            ...:.||  :|:.                                       .|::..|.:.:.:
Mouse   352 HQMVLCKKDLIRR---------------------------------------DILYYKGRIDMDK 377

  Fly   365 TWVGFIRDA--IDLHVQCRKTLRKDSSKRTPIRKKDMKKFGADYVLSPNKRKCEYDTVFRNKNRS 427
            ..|..|.|.  .|.:|..:...:..:.:...:.....||.         :.|..:...||.:.:.
Mouse   378 YEVIDIEDGRDDDFNVSMKNAFKLHNKETEEVHLFFAKKL---------EEKIRWLRAFREERKM 433

  Fly   428 TDSEEETEDSACFSRKRKVASGILRAPNGNPMGKASSSSSSSVSMKRVAPPPPAPPPPPAVQ 489
            ...:|:.......::||:.|..:.:|           |....|:..|..||...||..|..|
Mouse   434 VQEDEKIGFEISENQKRQAAMTVRKA-----------SKQKGVNSARSVPPSYPPPQDPLNQ 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	39/178 (22%)
		PH-like	269..>311	CDD:302622	10/44 (23%)
		PH	277..374	CDD:278594	14/101 (14%)
Arhgef9	XP_006528055.1	SH3_ARHGEF9	14..75	CDD:212908
		RhoGEF	114..293	CDD:214619	40/179 (22%)
		PH_Collybistin_ASEF	298..437	CDD:269931	26/186 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910