DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and ARHGEF12

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_056128.1	Gene:	ARHGEF12 / 23365	HGNCID:	14193	Length:	1544	Species:	Homo sapiens

Alignment Length:	284	Identity:	63/284 - (22%)
Similarity:	120/284 - (42%)	Gaps:	56/284 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQIEMIHNLN---------- 125
            |::.|.|:..:|::::..|::|...|.:.:..:.|:..|....:|..:|.|..|:
Human   788 RQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAV 852

  Fly   126 ------------GE-----FLRELEANMENVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISK 173
                        ||     |....|..:::.|..|....||             ||.:|:....|
Human   853 RKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPF-------------ALEMIKSRQKK 904

  Fly   174 NPVFRKFLEQTESRPEVQR-KLNSLMIVPIQRVPRYKLLLEQVLLYTS-PADADYKLLKESVKEI 236
            :..|:.|::..||.|..:| :|..::...:||:.:|.|||:.:..||. |.:.:  .:|::....
Human   905 DSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTERE--KVKKAADHC 967

  Fly   237 EATASHINTCVEEQEITQYLIHLQNSL------VNRTPNIVK------PSRRVIKEGVLQKITHK 289
            ....:::|..|:|.|..|.|...|..|      ::..||:.:      ..|::|.||.|....::
Human   968 RQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNR 1032

  Fly   290 GTEIKRYCVLMSDIFMYCKMIKER 313
            ...|..|.:|:.||.:..:...:|
Human  1033 DKTIDLYTLLLEDILVLLQKQDDR 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	41/198 (21%)
		PH-like	269..>311	CDD:302622	11/47 (23%)
		PH	277..374	CDD:278594	10/37 (27%)
ARHGEF12	NP_056128.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		PDZ_signaling	71..145	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..346
		RGS_LARG	349..570	CDD:188708
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..706
		RhoGEF	791..976	CDD:279015	41/199 (21%)
		PH_LARG	995..1132	CDD:275425	13/62 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1138..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810