Protein Alignment RhoGEF4 and Fgd5

DIOPT Version :9

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_006506063.1
• Gene: Fgd5 / 232237
• MGIID: 2443369
• Length: 1515
• Species: Mus musculus
• Alignment Length: 577
• Identity: 112/577 - (19%)
• Similarity: 209/577 - (36%)
• Gaps: 137/577 - (23%)

  Fly    37 LTAKSRRKVCSMLDSNNSSPIGSPNPD---AGKRLGFRRQAI--QEIISSEKSYLEQLE-LLMNF 95
            ::|..|..:.|..:..:|....|.:.|   :.|..|..|..:  ||::||||:|::.|: |.::|
Mouse   904 ISAAPREDLTSDEEQGSSEEEDSASRDPSLSHKGEGQSRALVIAQELLSSEKAYVQMLQHLSLDF 968

  Fly    96 FVRPLKEQAIIDCSNHTLL--------FGQIEMIHNLNGEFLRELEANM-------ENVAHAFLK 145
            ....|:....::......|        ..::..|.:|:...|..||..:       ..||..||.
Mouse   969 HGAVLRALENVEQEGREPLAQEELRQGLRELPAICDLHQGILESLEQRLGDCGEGQPQVADIFLA 1033

  Fly   146 MAPFFKLYSVYAFDYRGALFIIQDLISKNP----VFRKFLEQTESRPEVQRKLNSLMIVPIQRVP 206
            ....|:.::.:...:...|.::.:....:|    ..|:|.:|:........|...|.:|  ||:.
Mouse  1034 QEQEFEHHAAHILQFDRYLGLLAESCLLSPRLATTVREFEQQSSQGGGQSMKHRMLRVV--QRLF 1096

  Fly   207 RYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQEITQYLIHLQNSLVNRTPNIV 271
            :|::||...|....|..|:|...:.::..|.......|..:|:.|..|.|:|::.| |....:::
Mouse  1097 QYQVLLTDYLNNLCPDSAEYDNTQSALTLISKVTDRANESMEQGENLQKLVHIEYS-VRGQGDLL 1160

  Fly   272 KPSRRVIKEGVLQKITHKGTEIKRYCVLMSDIFMY----------------------CKMIKERA 314
            :|.|..:|||.|.::..|... .|:..||:|..:|                      .:.:.::.
Mouse  1161 QPGREFLKEGTLMRVRGKSRH-PRHLFLMNDTLLYTHPQKDGKYRLKSSLPVANMKVSRPVMDKV 1224

  Fly   315 PNTVVENSLECCCIFPLKKCK--------VYEMLPGNFKLTCQSDGIIFGSGDVQLSRTWVGFIR 371
            |..:...:.|.|.......|.        :...||.::|....:
Mouse  1225 PYALKIETPESCLTLSASSCAERDEWHYCLSRALPEDYKTQALA--------------------- 1268

  Fly   372 DAIDLHVQCRKTLRKDSSKR----TPIRKKDM-KKFGADYVLSPNKRKCEY--DTVFRNKNRSTD 429
             |....|:.|:.|.....:|    .|:....| ...|.|:.|:..:..|..  ..|.||.:|:
Mouse  1269 -AFHHSVEIRERLGISLGERLPTLVPVTHAMMCMNCGCDFSLTVRRHHCHACGKIVCRNCSRN-- 1330

  Fly   430 SEEETEDSACF-SRKRKVASGI---LRAPNGN--------------PMGKASSSSSSSVS--MKR 474
                .....|. :|..||..|.   |:..||.              |:..:..||.|::|  .:.
Mouse  1331 ----KYPLKCLKNRMAKVCDGCFRELKLRNGPVPGSMRERPVSMSFPLSSSRFSSGSALSSVFQS 1391

  Fly   475 VAPPPPAPPPPPAVQMRHQPGRPGELATASKENRISKLYKKIAAGDKVANVRGILKR 531
            ::|                       :|..|:.::.....::||..:.:.:.|.|.|
Mouse  1392 ISP-----------------------STFKKQKKVPSALSEVAASGEGSAISGYLSR 1425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	40/191 (21%)
		PH-like	269..>311	CDD:302622	12/63 (19%)
		PH	277..374	CDD:278594	17/126 (13%)
Fgd5	XP_006506063.1	2A1904	<95..339	CDD:273344
		RhoGEF	946..1134	CDD:366202	40/189 (21%)
		PH-like	1153..1275	CDD:388408	21/144 (15%)
		FYVE_like_SF	1289..1355	CDD:333710	16/71 (23%)
		PH2_FGD5_FGD6	1419..1509	CDD:270057	3/7 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X316
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910