Protein Alignment RhoGEF4 and Arhgef39

DIOPT Version :9

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_030109277.1
• Gene: Arhgef39 / 230098
• MGIID: 3036286
• Length: 350
• Species: Mus musculus
• Alignment Length: 372
• Identity: 88/372 - (23%)
• Similarity: 162/372 - (43%)
• Gaps: 46/372 - (12%)

  Fly    30 VLQERNLLTAKSRRKVCSMLDSNNSSPIGSPNPDAGKRLGFRRQAIQEIISSEKSYLEQLELLMN 94
            |||:|   ....|::||:                           .:|::.:|:.|.|||.|:..
Mouse    12 VLQQR---ARWERKRVCT---------------------------ARELLETERRYQEQLGLVAT 46

  Fly    95 FFVRPLKEQAIIDCSNHTLLFGQIEMIHNLNGEFLRELEANMENVAHAFLKMAPFFKLYSVYAFD 159
            :|:|.||.:..:.......|||..|:|:..:.|.|..||.....:  ......|..:||:.:|.:
Mouse    47 YFLRILKAKGTLRPPELQTLFGTWELIYAASLELLPYLEEGQWGL--GLQGFCPHLELYAQFAAN 109

  Fly   160 YRGALFIIQDLISKNPVFRKFLEQTESRPEVQ-RKLNSLMIVPIQRVPRYKLLLEQVLLYTSPAD 223
            ...:...:|..:.||..||:|::..|.|||.: .:|..|:.:|:||:.:|:.|:..:...|.|..
Mouse   110 AERSQTTLQAQLKKNKRFRRFVKLQEGRPEFRGLQLQDLLPLPLQRLQQYENLVVALAENTVPNS 174

  Fly   224 ADYKLLKESVKEIEATASHINTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITH 288
            .||:.|..:.:.:..||..::...:.|:..|:|:.:|..|..|....:...|..:::|.|..:..
Mouse   175 PDYQQLTRAARLVSETAQKVHAIGQSQKNDQHLLRVQALLSGRKAKGLTSGRWFLRQGWLLVVPP 239

  Fly   289 KGTEIKRYCVLMSDIFMYCKMIKERAP-NTVVENSLECCCIFPLKKCKVYEML-------PGNFK 345
            .|....|...|.||:.:   |.|.|.| :.:...:..|..::|:.:|.:..:.       .|...
Mouse   240 TGEPRPRMFFLFSDVLL---MAKPRPPLHLLKSGTFVCRALYPMSQCHLSRVFGHSGGPCGGLLS 301

  Fly   346 LTCQSDGIIFGSGDVQLSRTWVGFIRDAIDLHVQCRKTLRKDSSKRT 392
            |:...:.::..|.|.:....|...:..||.|....|.  :|.|:.|:
Mouse   302 LSFPHEKLLLMSTDQEELSQWHHSLTLAIRLFSSHRS--QKSSTHRS 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	48/170 (28%)
		PH-like	269..>311	CDD:302622	9/41 (22%)
		PH	277..374	CDD:278594	19/104 (18%)
Arhgef39	XP_030109277.1	RhoGEF	27..195	CDD:366202	48/169 (28%)
		PH-like	199..>255	CDD:388408	14/55 (25%)
		PH	228..331	CDD:214574	20/105 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H19225
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008364
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107378
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7163
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840