DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF4 and ARHGEF15

DIOPT Version :9

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:XP_011522036.1 Gene:ARHGEF15 / 22899 HGNCID:15590 Length:856 Species:Homo sapiens


Alignment Length:549 Identity:119/549 - (21%)
Similarity:201/549 - (36%) Gaps:186/549 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 GSPNP-DAGKRLGFRR--------------------------------QAIQEIISSEKSYLEQL 89
            |||:| :||....|.|                                :::.|:::||.|||..|
Human   372 GSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSL 436

  Fly    90 ELLMNFFVRPLKEQAIIDC---SNHTLLFGQIEMIHNLNGEFLRELEANME---------NVAHA 142
            .||.:.||   ..||:.|.   .:|..||..::.:..::..||..|.:.:.         :|.||
Human   437 RLLTDTFV---LSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHA 498

  Fly   143 FLKMAPFFKLYSVYAFDYRGALF---IIQDLISKNPVFRKFLEQTESRPEVQR-KLNSLMIVPIQ 203
            . .:.||    |||....|...:   ....|:..|..|...|.:.:|.|:.:| .|.|.:::|.|
Human   499 H-AVGPF----SVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQ 558

  Fly   204 RVPRYKLLL---------------EQVLLYT----SPADADYKLLKESVKEIEATASHINTCVEE 249
            |:.|.::||               :.:|..|    |..:...|.|....|.||..::.:....:.
Human   559 RITRLRMLLQGHRAGGPVTLPPCPQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQT 623

  Fly   250 QEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKI-THKGTEI----KRY---CVLM-SDIFM 305
            :|:.:....|:...|...| :|..|||:..:|.|.:: ..:|..:    .|:   |:|: ||:.:
Human   624 EELIRLTQRLRFHKVKALP-LVSWSRRLEFQGELTELGCRRGGVLFASRPRFTPLCLLLFSDLLL 687

  Fly   306 YCK-------MIKERAPNTVVENSLECCCIFPLKKCKVYEML-PGNFKLTCQSDGIIFGSGDVQL 362
            ..:       .:.:.|..::|:..            :|.:.. |..|:|:..|:           
Human   688 ITQPKSGQRLQVLDYAHRSLVQAQ------------QVPDPSGPPTFRLSLLSN----------- 729

  Fly   363 SRTWVGFIRDAIDLHVQCRKT--LRKDSSKRTPIRKKDMKKF-GADYVLSPNKRKCEYDTVFRNK 424
                          | |.|.|  |.:.||      ..||::: ||  ..:|....|..||::.:.
Human   730 --------------H-QGRPTHRLLQASS------LSDMQRWLGA--FPTPGPLPCSPDTIYEDC 771

  Fly   425 NRSTD--SEE----ETEDSACFSRK-----RKVASGILRA-PNGNP------------------- 458
            :.|.:  ||.    :||..:..||.     .|...|.|:. |...|                   
Human   772 DCSQELCSESSAPAKTEGRSLESRAAPKHLHKTPEGWLKGLPGAFPAQLVCEVTGEHERRRHLRQ 836

  Fly   459 ---MGKASSSSSSSVSMKRVAPPPPAPPP 484
               :.:|..|||.:         |.||||
Human   837 NQRLLEAVGSSSGT---------PNAPPP 856

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:279015 52/204 (25%)
PH-like 269..>311 CDD:302622 12/57 (21%)
PH 277..374 CDD:278594 15/113 (13%)
ARHGEF15XP_011522036.1 RhoGEF 422..613 CDD:279015 52/198 (26%)
PH_ephexin 637..757 CDD:269929 32/166 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.