DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and FGD1

DIOPT Version :10

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_004454.2 Gene:FGD1 / 2245 HGNCID:3663 Length:961 Species:Homo sapiens


Alignment Length:374 Identity:97/374 - (25%)
Similarity:164/374 - (43%) Gaps:71/374 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 EIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTL--------LFGQIEMIHNLNGEF-LREL 132
            |::.:||:|:.:|.||...|...|.|:|    .|.:.        :|..|..|:..:.:| |.||
Human   380 ELLQTEKAYVSRLHLLDQVFCARLLEEA----RNRSSFPADVVHGIFSNICSIYCFHQQFLLPEL 440

  Fly   133 EANME------NVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQTESRPEVQ 191
            |..||      .:.....|:|||.|:|..|..::..|:.::.....::..|:..:.      |||
Human   441 EKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIH------EVQ 499

  Fly   192 RK-------LNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEE 249
            ::       |...|:.|:||:|||:|||:..||.......|.|..::|::.|...|.|.|..:.:
Human   500 KEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRK 564

  Fly   250 QEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHK-GTEIKRYCVLMSDIFMYC------ 307
            .|....|:.:. .|:....:||.|::.:||||.:.|::.| ||...||.:|.:|..:||      
Human   565 MERMHKLLKVY-ELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRL 628

  Fly   308 --KMIKERAPNTVVENSLECCCIFPLKKCKVYEMLPGNFKLTCQSDGIIFGSGDVQLSRTWVGFI 370
              :....||...|  :.:|      ||:..... ||..|.::.:...:...:...:..:.||..|
Human   629 LGQKFSVRARIDV--DGME------LKESSNLN-LPRTFLVSGKQRSLELQARTEEEKKDWVQAI 684

  Fly   371 RDAIDLHVQCRKTLR------------------KDSSKR--TPIRKKDM 399
            ...:..|.|..:|.:                  .|..||  ||||:|::
Human   685 NSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEV 733

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:459876 53/188 (28%)
PH-like 269..>311 CDD:473070 17/50 (34%)
PH 277..374 CDD:459697 26/105 (25%)
FGD1NP_004454.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..353
PHA03247 <50..332 CDD:223021
SH3-binding. /evidence=ECO:0000255 171..187
RhoGEF 376..559 CDD:238091 53/188 (28%)
PH1_FGD1 591..698 CDD:275392 28/115 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 702..726 3/23 (13%)
FYVE_FGD1_2_4 725..789 CDD:277280 5/9 (56%)
PH2_FGD1-4 815..920 CDD:270056
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 925..961
Blue background indicates that the domain is not in the aligned region.

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