Protein Alignment RhoGEF4 and FGD2

DIOPT Version :9

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: XP_016865918.1
• Gene: FGD2 / 221472
• HGNCID: 3664
• Length: 662
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 86/326 - (26%)
• Similarity: 161/326 - (49%)
• Gaps: 47/326 - (14%)

  Fly     4 PRQK-GYGNGFIHSPQTPLSFSRELRQVLQERNLLTAKSRRKVCSMLDSNNSSPIGSPNPDAGKR 67
            ||:| ..|......|:|   .||  |.:...:|.|::::.||.|..:..:.|   |:..|:
Human    51 PREKTNVGEAVGSEPRT---VSR--RYLNSLKNKLSSEAWRKSCQPVTLSGS---GTQEPE---- 103

  Fly    68 LGFRRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQA---------IIDCSNHTLLFGQIEMIHN 123
                ::.:||::.:|::|:.:|.||...|.:.|.:.|         ::     .::|..|..|:.
Human   104 ----KKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVV-----RVIFSNISSIYQ 159

  Fly   124 LNGE-FLRELEANMEN------VAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFL 181
            .:.: ||.||:..:::      :.....|:|||.|:||.|..::..|..::.....|:|:|::.|
Human   160 FHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVL 224

  Fly   182 EQTE-SRPEVQRKLNSLMIVPIQRVPRYKLLLE---QVLLYTSPADADYKLLKESVKEIEATASH 242
            .:.: |.......|...|:.|:||:|||:|||:   |.|...:|..||   .::::..|.:.|.|
Human   225 TRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQAD---AQKALDMIFSAAQH 286

  Fly   243 INTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKGTE-IKRYCVLMSDIFMY 306
            .|..:.|.|..|.|..:...| ....:||.||..:::||.:.||:.:..: ::||..|.:::.:|
Human   287 SNAAITEMERLQDLWEVYQRL-GLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLY 350

  Fly   307 C 307
            |
Human   351 C 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	50/189 (26%)
		PH-like	269..>311	CDD:302622	13/40 (33%)
		PH	277..374	CDD:278594	9/32 (28%)
FGD2	XP_016865918.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7163
SonicParanoid	1	1.000	-	-		X316
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.800