DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and FGD2

DIOPT Version :10

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_775829.2 Gene:FGD2 / 221472 HGNCID:3664 Length:655 Species:Homo sapiens


Alignment Length:326 Identity:86/326 - (26%)
Similarity:161/326 - (49%) Gaps:47/326 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PRQK-GYGNGFIHSPQTPLSFSRELRQVLQERNLLTAKSRRKVCSMLDSNNSSPIGSPNPDAGKR 67
            ||:| ..|......|:|   .||  |.:...:|.|::::.||.|..:..:.|   |:..|:    
Human    51 PREKTNVGEAVGSEPRT---VSR--RYLNSLKNKLSSEAWRKSCQPVTLSGS---GTQEPE---- 103

  Fly    68 LGFRRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQA---------IIDCSNHTLLFGQIEMIHN 123
                ::.:||::.:|::|:.:|.||...|.:.|.:.|         ::     .::|..|..|:.
Human   104 ----KKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVV-----RVIFSNISSIYQ 159

  Fly   124 LNGE-FLRELEANMEN------VAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFL 181
            .:.: ||.||:..:::      :.....|:|||.|:||.|..::..|..::.....|:|:|::.|
Human   160 FHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVL 224

  Fly   182 EQTE-SRPEVQRKLNSLMIVPIQRVPRYKLLLE---QVLLYTSPADADYKLLKESVKEIEATASH 242
            .:.: |.......|...|:.|:||:|||:|||:   |.|...:|..||   .::::..|.:.|.|
Human   225 TRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQAD---AQKALDMIFSAAQH 286

  Fly   243 INTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKGTE-IKRYCVLMSDIFMY 306
            .|..:.|.|..|.|..:...| ....:||.||..:::||.:.||:.:..: ::||..|.:::.:|
Human   287 SNAAITEMERLQDLWEVYQRL-GLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLY 350

  Fly   307 C 307
            |
Human   351 C 351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:459876 50/189 (26%)
PH-like 269..>311 CDD:473070 13/40 (33%)
PH 277..374 CDD:459697 9/32 (28%)
FGD2NP_775829.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..64 4/12 (33%)
RhoGEF 104..288 CDD:238091 50/191 (26%)
PH1_FGD2 320..427 CDD:275421 9/32 (28%)
FYVE_FGD1_2_4 453..517 CDD:277280
PH2_FGD1-4 538..640 CDD:270056
Blue background indicates that the domain is not in the aligned region.

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