Protein Alignment RhoGEF4 and exc-5

DIOPT Version :10

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_001294029.1
• Gene: exc-5 / 177692
• WormBaseID: WBGene00001366
• Length: 861
• Species: Caenorhabditis elegans
• Alignment Length: 471
• Identity: 113/471 - (23%)
• Similarity: 200/471 - (42%)
• Gaps: 66/471 - (14%)

  Fly     7 KGYGNGFIHSPQTPLSFSRELRQVLQERNLLTAKSRRKVCSMLDSNNSSPIGSPNPDAGKRLGFR 71
            ||...||    |..||...|......|:........:...|.:||.:.....||..|..||....
 Worm   273 KGPDGGF----QVKLSDGDEFELSEDEQEDDDTSLSQSCYSEIDSESDITGPSPKTDLDKRYQKA 333

  Fly    72 RQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQIEMIHNL-NGEFLRELEAN 135
            ..|.:|::.||:.|:::|:||.:.|...|.::.:|.....|.|...:..::.. |..||.:|..:
 Worm   334 WYAAKELVDSEQRYVDKLKLLGDTFRNRLIKEELITNDKITRLLANVSSLYQFHNTHFLPQLLES 398

  Fly   136 M------ENVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQTESRPEVQ-RK 193
            :      :.:|:...|.|||.|:||.|..:|..|..:.::| .|...|...:::.|.:.|.: ..
 Worm   399 IRDWHTTKRIANVVRKQAPFLKMYSEYTNNYDRATKLFEEL-KKKKKFADVVKEIEKQAECEGLP 462

  Fly   194 LNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEEQEITQYLIH 258
            |...:|.|:|||.||:|||::...:..|:|.|:.....:::.:...|:|.|..:::.:....:|.
 Worm   463 LGHHLICPVQRVMRYQLLLQEYKKHLQPSDVDFDDTTVALELVLQAAAHANEMMKKLDRFGKVIE 527

  Fly   259 LQNSLVNRTPNIVKPSRRVIKEGVLQKI--THKGTEIKRYCVLMSDIFMYCKMIKERAPNTVVEN 321
            :|..|.| :.::|.|.|.::|.|.:|||  |.:.|| :|:..|.:|:.:   :..||.
 Worm   528 VQEQLGN-SISLVSPGRELLKSGSVQKISSTTEKTE-ERFIFLFNDLVI---LASERK------- 580

  Fly   322 SLECCCIFPLKKCKVYEMLPGNFKLTCQSDGI----------IFGSGD---VQL-------SRTW 366
                  :..:.|.|:..:...:....|:.|.:          ..|:|.   |:|       ...|
 Worm   581 ------MIGVSKYKLRAVFSASHMQVCEGDNLEREHSFYLRGSDGTGPKRCVELFTPTQKEKNDW 639

  Fly   367 VGFIRDAID---LHVQCRKTLRKDSSKRTPIRKKDMKKFGADYVLSPNKRKCEYDTVFRNKNRST 428
            |..|...||   .|     :|...||.|:.|.:.:...     :.|.:...|:.:..|.::....
 Worm   640 VDSIFSIIDEAKAH-----SLTFTSSSRSSISENNNNS-----IESKHCADCDIEFGFLSRGSKC 694

  Fly   429 DSEEETEDSACFSRKR 444
            ..........||.|:|
 Worm   695 VKCSRRLCKKCFGRRR 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:459876	49/177 (28%)
		PH-like	269..>311	CDD:473070	14/43 (33%)
		PH	277..374	CDD:459697	24/118 (20%)
exc-5	NP_001294029.1	RhoGEF	336..514	CDD:214619	49/178 (28%)
		PH1_FGD1-4_like	545..643	CDD:275423	23/114 (20%)
		FYVE	676..727	CDD:214499	6/35 (17%)
		PH-like	<773..845	CDD:473070