Protein Alignment RhoGEF4 and ZK632.12

DIOPT Version :10

• Sequence 1: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_499183.1
• Gene: ZK632.12 / 176397
• WormBaseID: WBGene00014019
• Length: 266
• Species: Caenorhabditis elegans
• Alignment Length: 275
• Identity: 52/275 - (18%)
• Similarity: 91/275 - (33%)
• Gaps: 114/275 - (41%)

  Fly   259 LQNSLVN--RTPNIVKP-----------SRRVIKEGVLQKITHKGTEIKRYCVLMSDIFMYCKMI 310
            |.||.||  |..|:.:.           .|.::.||||.|:..|..: :|...|.:||.:|..::
 Worm     5 LVNSEVNSRRMANVEQCFGKMGEQLSVFGRVLVGEGVLVKMCRKKPK-QRQFFLFNDILVYGNIV 68

  Fly   311 -------KERAPNTVVENSLECCCIFPLKKCKVYEMLPGNFKLTCQSDGI--------------- 353
                   |:|              |..|:..:|.::         :.|||
 Worm    69 ISKKRYNKQR--------------ILRLEGVQVEDL---------EDDGIEKHGWIIKTPAKSFA 110

  Fly   354 IFGSGDVQLSRTWVGFI------------RDAIDLHV---------------------------Q 379
            ::.:.:.: .|.|:..|            :.|...|.                           .
 Worm   111 VYAATETE-KREWMLHIERCVTDLLERGNKQAATAHAAVWVPDGEAVKCMVCGKTQFNLVQRRHH 174

  Fly   380 CR------------KTLRKDSSKRTPIRKKDMKKFGADYVLSPNKRKCEYDTVFR--NKNRSTDS 430
            ||            :|.|.|:..:.|:|..| ..|.:....:|.:.:.|..|..|  :::.|:||
 Worm   175 CRNCGRVVCGACSSRTFRIDNVHKKPVRVCD-HCFDSLSSATPGQEESEPKTGNRLHHEDSSSDS 238

  Fly   431 EEETEDSACFSRKRK 445
            |:|...|...|.:.:
 Worm   239 EDEVNGSGRSSNESR 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:459876
		PH-like	269..>311	CDD:473070	13/59 (22%)
		PH	277..374	CDD:459697	22/130 (17%)
ZK632.12	NP_499183.1	PH_Phafin2-like	7..129	CDD:269927	29/146 (20%)
		FYVE_PKHF	148..208	CDD:277257	8/60 (13%)