DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and ephx-1

DIOPT Version :9

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_494706.2 Gene:ephx-1 / 173742 WormBaseID:WBGene00019487 Length:1159 Species:Caenorhabditis elegans


Alignment Length:587 Identity:124/587 - (21%)
Similarity:207/587 - (35%) Gaps:205/587 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 RRQAIQEIISSEKSYLEQLELLMNFFVR------PLKEQAIIDCSNHTLLFGQIEMIHNLNGEFL 129
            |::|..|:|:||.|||..|.:|:..|:.      .....:::..|:...||..|..:.:.:...|
 Worm   682 RQEAYFEVITSEASYLRSLNVLITHFMASPQMLGSKSALSVLSDSDRKHLFSNIFAVRDCSERLL 746

  Fly   130 RELEANMEN----------VAHAFLKMAPFFKLYSVYAFDYRGALFIIQD-----LISKNPVFRK 179
            .:||..:|.          ::..|.|   .|::|..|..:.     :.||     |.::||.|..
 Worm   747 CDLETRLEENLILDDICDILSDHFDK---HFEVYIKYCSNQ-----VYQDRTLRRLKTENPGFLS 803

  Fly   180 FLEQTESRPEVQ-RKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHI 243
            .:::.|...:.| ..:.|.:::|:|||.||.|||..:|...:..|..||...:::..........
 Worm   804 AVQRLEENKQCQGLDMRSFLMLPMQRVTRYPLLLYAILDRITTTDDRYKTATDALTSSNRVVRDC 868

  Fly   244 NTCVEEQEITQYLIHLQNSLV------NRTPNIVKPSRRVIKEGVL-QKITHKGTEIKR------ 295
            |......|.|:.|:.:...|:      .|.| :|..||.::|:||| |.:..:.:.|.:      
 Worm   869 NEGARRMERTEQLLDIDRRLIYKDADLKRIP-LVSNSRYLVKKGVLTQLVERRSSNILQSRQKAR 932

  Fly   296 --YCVLMSDIFMYCKMIKERAPNTVVENSLECCCIFPLKKCKVYEMLPGNFKLTCQSDGIIFGSG 358
              :..|.||:.|   :.|::...|.|              ||.|.                    
 Worm   933 TLHVFLFSDMIM---ITKKKLNGTFV--------------CKDYA-------------------- 960

  Fly   359 DVQLSRTWVGFIRDAIDLHVQCRKTLRKDSSKRTPIRKKDMK-KFGA--DYVLSPNKRKCEYDTV 420
                       .|..:|:.               ||...:.| ..||  :.|..|:...|   |:
 Worm   961 -----------ARRFVDMQ---------------PIEPDNPKIPLGATSNLVGRPHLFLC---TL 996

  Fly   421 FRN-KNRSTD----SEEETEDSACFSRKRKVASGILRAPNGNPMGKASSSSSSSVSMKRVAPPPP 480
            .|| :::.|:    ::.||:      |:|.:::                          |.||..
 Worm   997 MRNARDKQTELLLSADSETD------RERWLSA--------------------------VRPPTS 1029

  Fly   481 APP----------PPPAVQMRHQPGRPGELA--TASKENRISK-----LYKKIAAGDKVANVRGI 528
            ..|          |...|...:||.:..||.  .....|.:.|     ||.: .|||   .:.|.
 Worm  1030 TNPEEKIYAEWDCPQALVVHAYQPSQADELQLNIGDSLNILRKMPDGWLYGE-RAGD---GLGGW 1090

  Fly   529 LKRSNVPAPNNDHDPS----------------YGFAS----------------RYSDSKSYFRAH 561
            ...|.|.|..|||..:                :|.||                |.|:.|:||::.
 Worm  1091 FPSSYVQAIINDHTRANNYRQRLRIIQAASGWHGNASPSSTRSGGMPLMDRLRRMSNPKTYFQSG 1155

  Fly   562 NV 563
            .|
 Worm  1156 TV 1157

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:279015 46/191 (24%)
PH-like 269..>311 CDD:302622 13/50 (26%)
PH 277..374 CDD:278594 17/105 (16%)
ephx-1NP_494706.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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