DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and Fgd1

DIOPT Version :9

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_032027.2 Gene:Fgd1 / 14163 MGIID:104566 Length:960 Species:Mus musculus


Alignment Length:374 Identity:97/374 - (25%)
Similarity:164/374 - (43%) Gaps:71/374 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 EIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTL--------LFGQIEMIHNLNGEF-LREL 132
            |::.:||:|:.:|.||...|...|.|:|    .|.:.        :|..|..|:..:.:| |.||
Mouse   379 ELLQTEKAYVSRLHLLDQVFCARLLEEA----RNRSSFPADVVHGIFSNICSIYCFHQQFLLPEL 439

  Fly   133 EANME------NVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQTESRPEVQ 191
            |..||      .:.....|:|||.|:|..|..::..|:.::.....::..|:..:.      |||
Mouse   440 EKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIH------EVQ 498

  Fly   192 RK-------LNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASHINTCVEE 249
            ::       |...|:.|:||:|||:|||:..||.......|.|..::|::.|...|.|.|..:.:
Mouse   499 KEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRK 563

  Fly   250 QEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHK-GTEIKRYCVLMSDIFMYC------ 307
            .|....|:.:. .|:....:||.|::.:||||.:.|::.| ||...||.:|.:|..:||      
Mouse   564 MERMHKLLKVY-ELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRL 627

  Fly   308 --KMIKERAPNTVVENSLECCCIFPLKKCKVYEMLPGNFKLTCQSDGIIFGSGDVQLSRTWVGFI 370
              :....||...|  :.:|      ||:.....| |..|.::.:...:...:...:..:.||..|
Mouse   628 LGQKFSVRARIDV--DGME------LKESSNLNM-PRTFLVSGKQRSLELQARTEEEKKDWVQAI 683

  Fly   371 RDAIDLHVQCRKTLR------------------KDSSKR--TPIRKKDM 399
            ...:..|.|..:|.:                  .|..||  ||||:|::
Mouse   684 NSTLLKHEQTLETFKLLNSTNRDDEDTPPNSPNVDLGKRAPTPIREKEV 732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:279015 53/188 (28%)
PH-like 269..>311 CDD:302622 17/50 (34%)
PH 277..374 CDD:278594 26/105 (25%)
Fgd1NP_032027.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..210
SH3-binding. /evidence=ECO:0000255 171..187
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..355
RhoGEF 375..558 CDD:238091 53/188 (28%)
PH1_FGD1 590..697 CDD:275392 28/115 (24%)
PH 590..687 CDD:278594 26/105 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 701..725 3/23 (13%)
FYVE_FGD1_2_4 724..788 CDD:277280 5/9 (56%)
PH2_FGD1-4 814..919 CDD:270056
PH 822..920 CDD:278594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 922..960
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X316
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.770

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