DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and Arhgef5

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	XP_038964580.1	Gene:	Arhgef5 / 140898	RGDID:	620718	Length:	1589	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	98/388 - (25%)
Similarity:	167/388 - (43%)	Gaps:	87/388 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 RQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQIEMIHNLNGEFLRELEANM 136
            ::|..|:|.||.|||..|.:.::.|....:.:|.:...:|..||.:::.:.:::..||.:||.|.
  Rat  1168 QEAKFELIVSEASYLRSLNIAVDHFQHSTQLRATLSNQDHQWLFSRLQDVRDVSTTFLSDLEENF 1232

  Fly   137 EN------VAHAFLKMAP-FFKLYSVYAFD--YRGALFIIQDLISKNPVFRKFLEQTESRPEVQR 192
            ||      |....|..|| |.::|..|..:  |:...|  |.|::.|..||:.||:.||.|..||
  Rat  1233 ENNIFSFQVCDVVLDHAPDFHRVYLPYVTNQTYQERTF--QSLMNSNSSFREVLEKLESDPVCQR 1295

  Fly   193 -KLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASH---------INTCV 247
             .|.|.:|:|.||:.|.||||:.:|..|.|.         |.:|.|||.:|         .|:.|
  Rat  1296 LSLKSFLILPFQRITRLKLLLQNILKRTQPG---------SSEEAEATKAHHALEKLIRDCNSNV 1351

  Fly   248 EEQEITQYLIHLQNSLVNRTP--NIVKPSRRVIKEGVL------------QKITHKGTEIKRY-- 296
            :....|:.||:|...:.....  .::..||.::|.|.|            :|:|.:...:..:
  Rat  1352 QRMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEFSVSPGLKRKLTTRPVHLHLFND 1416

  Fly   297 CVLMS-----DIFMYCKMIKERAPNTVVENSLECCCIFPLKKCKVYEMLPGNFK------LTCQS 350
            |:|:|     ..|    ::.:.||.:.:..          :||::  .|.|..|      |...:
  Rat  1417 CLLLSRPREGSRF----LVFDHAPFSSIRG----------EKCEM--KLHGAHKNLFRLFLLHNA 1465

  Fly   351 DG----IIFGSGDVQLSRTWVGFI---RDAIDL-------HVQCRKTLRKDSSKRTPIRKKDM 399
            .|    .:|.:........|:..:   |:.:||       .|||.:..:...:....:.|.|:
  Rat  1466 QGTQAEFLFRTETQSEKLRWISALAMPREELDLLECYDSPQVQCLRAYKPRENDELALEKADV 1528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	62/188 (33%)
		PH-like	269..>311	CDD:302622	11/60 (18%)
		PH	277..374	CDD:278594	21/128 (16%)
Arhgef5	XP_038964580.1	ARHGEF5_35	1..478	CDD:406010
		PHA03247	<395..840	CDD:223021
		RhoGEF	1172..1348	CDD:395496	61/186 (33%)
		PH_ephexin	1370..1496	CDD:269929	23/141 (16%)
		SH3_ARHGEF5_19	1506..1560	CDD:212873	5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910