DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and ARHGEF19

DIOPT Version :9

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:NP_694945.2 Gene:ARHGEF19 / 128272 HGNCID:26604 Length:802 Species:Homo sapiens


Alignment Length:360 Identity:80/360 - (22%)
Similarity:148/360 - (41%) Gaps:63/360 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 NGFIHSPQTPLSFSRELRQVLQER-------------------NLLTAKSRRKVCSMLDSNNSSP 56
            |..::...:.::.:||||:..:|.                   ||..:.|.|...|...|..|  
Human   291 NSVLYQEYSDVASARELRRQQREEEGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGSTFS-- 353

  Fly    57 IGSPNPDAG-----KRLGFR----RQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHT 112
            :....||..     ..|..|    ::|..|:|:||.||:..|.:.:..|:...:....:...:..
Human   354 LWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQ 418

  Fly   113 LLFGQIEMIHNLNGEFLRELEANME------NVAHAFLKMAPFF-KLYSVYAFDYRGALFIIQDL 170
            .||.::..:.:.:..||::||..:|      :|....|...|.| ::|..|..:........|.|
Human   419 WLFSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRL 483

  Fly   171 ISKNPVFRKFLEQTESRPEVQR-KLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVK 234
            :.:||.|...|.:.|..|..|| .|.|.:|:|.||:.|.|:|:|.:|..|:....|..:..::..
Human   484 LLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFN 548

  Fly   235 EIEATASHINTCVEEQEITQYLIHLQNSL--VNRTPNIVKPSRRVIKEGVL-------------Q 284
            .::......|..|:..:.|:.||||...:  ..:...::..:|.:::.|.|             .
Human   549 ALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKL 613

  Fly   285 KITHKGTEIKRY--CVLMS--------DIFMYCKM 309
            |::.|...:..:  |:|:|        .:|::.||
Human   614 KLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKM 648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:279015 45/177 (25%)
PH-like 269..>311 CDD:302622 11/64 (17%)
PH 277..374 CDD:278594 10/56 (18%)
ARHGEF19NP_694945.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Herpes_ICP4_C 10..>353 CDD:332854 12/61 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 84..138
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 171..190
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 222..283
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 306..342 7/35 (20%)
RhoGEF 382..558 CDD:306973 44/175 (25%)
PH_ephexin 580..706 CDD:269929 11/69 (16%)
SH3_ARHGEF5_19 719..773 CDD:212873
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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