DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF4 and Arhgef28

DIOPT Version :9

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:XP_006517581.1 Gene:Arhgef28 / 110596 MGIID:1346016 Length:1714 Species:Mus musculus


Alignment Length:489 Identity:84/489 - (17%)
Similarity:197/489 - (40%) Gaps:87/489 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 RRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQI-EMIHNLNGEFLRELEA 134
            |:..|.|::.:|..:::.|.::...|.:.:||:..:|.|....:|..: |::......|....|.
Mouse   861 RQDVIFELMQTEVHHIQTLLIMSEVFRKGMKEELQLDHSTVDKIFPCLDELLETHRHFFFSMKER 925

  Fly   135 NMENVAHA---FL------------------KMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFR 178
            ..|:.|.:   |:                  ||.   ::|..:...::.|:.:.::| .:|..|:
Mouse   926 RQESCAGSDRNFVINQIGDILVQQFSEENASKMK---RIYGEFCSHHKEAMSLFKEL-QQNKKFQ 986

  Fly   179 KFLEQTESRPEVQRK-LNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATASH 242
            .|::...|....:|: :...:::..||:.:|.:|:|::|.||.....:::.|.:::..|:...:.
Mouse   987 NFIKIRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHRDLCKALGLIKDMIAA 1051

  Fly   243 INTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQK---ITHKG-----TEIKRY--- 296
            ::..|.|.|..|..:.:.|.:.|:|...:|......|:.:|.:   :.|.|     |...|:   
Mouse  1052 VDLKVSEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALLSQERALLHDGLVYWKTATGRFKDI 1116

  Fly   297 -CVLMSDIFMYCKMIKERAPNTVVENSLECCCIFPLKKCKVYEMLPGNFKLTCQSDG---IIFGS 357
             .:|::|:.::.:...::.....|:.......:..|...:|.....|.|.::..|.|   ....:
Mouse  1117 LALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHT 1181

  Fly   358 GDVQLSRTWVGFIRDAIDLHVQCRKTLRKDSSKRTPIRKKDMKKFGADYVLSPNKRKCEYDTVFR 422
            ...:....|:..|:.|::       :..::...||....::.:|..|...   ..::|:  .:..
Mouse  1182 NSKEERNNWMRRIQQAVE-------SCPEEEGGRTSESDEERRKAEARVA---KIQQCQ--EILS 1234

  Fly   423 NKNRS--TDSEEETEDSACFSRKRKVASGILRAPNGNPMGKASSSSSSSVSMKRVAPPPPAPPPP 485
            |:::.  |..||:....|                   .:|:.|......:....:..|.|..||.
Mouse  1235 NQDQQICTYLEEKLHIYA-------------------ELGELSGFEDVHLEPHLLIKPDPGEPPQ 1280

  Fly   486 PA------------VQMRHQPGRPGELATASKEN 507
            .|            :|:..:..:.|:::.:|:|:
Mouse  1281 AASLLAAALREAESLQVAVKASKMGDVSQSSEES 1314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:279015 36/192 (19%)
PH-like 269..>311 CDD:302622 9/53 (17%)
PH 277..374 CDD:278594 17/111 (15%)
Arhgef28XP_006517581.1 C1 666..711 CDD:237996
RhoGEF 861..1053 CDD:238091 37/195 (19%)
PH_p190RhoGEF 1098..1198 CDD:275430 15/99 (15%)
xseA <1364..1520 CDD:234714
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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