DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF4 and Prex2

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	XP_006495504.1	Gene:	Prex2 / 109294	MGIID:	1923385	Length:	1617	Species:	Mus musculus

Alignment Length:	275	Identity:	68/275 - (24%)
Similarity:	125/275 - (45%)	Gaps:	25/275 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 DAGKRLGFRRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHT------LLFGQIEMI 121
            :..|:|..|...:.|:..:|:.|:..||.|::.|:..:.:.|......:.      :||..||.|
Mouse     8 EVDKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAAAKVDKNVTEETVKMLFSNIEEI 72

  Fly   122 HNLNGEFLRELE-------ANMENVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRK 179
            ..::.|||:.:|       :..:.|...||.....|::|..|..::..|..::.:| :|....|.
Mouse    73 LIVHKEFLKVVEECLYPEPSAQQEVGACFLHFKDKFRIYDEYCSNHEKAQKLLLEL-NKIRTIRT 136

  Fly   180 FLEQ---TESRPEVQRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATAS 241
            ||..   ...|......|...::.||||:.:|.|||:::|..|....:||..:.|:::.::|..|
Mouse   137 FLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRRHSDYTAVMEALQAMKAVCS 201

  Fly   242 HINTCVEEQE----ITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKGTEIKRYCVLMSD 302
            :||....:.|    :.::..|::..   ...||......::..|||.||: .|...:|...|..:
Mouse   202 NINEAKRQMEKLEVLEEWQAHIEGW---EGSNITDTCTEMLMCGVLMKIS-SGNIQERVFFLFDN 262

  Fly   303 IFMYCKMIKERAPNT 317
            :.:|||....|..|:
Mouse   263 LLVYCKRKHRRLKNS 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	46/185 (25%)
		PH-like	269..>311	CDD:302622	13/41 (32%)
		PH	277..374	CDD:278594	13/41 (32%)
Prex2	XP_006495504.1	RhoGEF	19..204	CDD:366202	46/185 (25%)
		PH_Collybistin_ASEF	210..356	CDD:269931	17/72 (24%)
		DEP_1_P-Rex	374..454	CDD:239886
		DEP_2_P-Rex	466..558	CDD:239887
		PDZ_signaling	587..662	CDD:238492
		PDZ_signaling	669..736	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910