DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF4 and arhgef11

DIOPT Version :9

Sequence 1:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	XP_017952119.2	Gene:	arhgef11 / 100489979	XenbaseID:	XB-GENE-992398	Length:	1607	Species:	Xenopus tropicalis

Alignment Length:	813	Identity:	165/813 - (20%)
Similarity:	269/813 - (33%)	Gaps:	262/813 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IHSPQTPLSFSRE-LRQVLQERNLLTAKSRRKVCSMLDSNNSSPIGSPNPDA-------GKRLGF 70
            |.||.  |.|:.| |...|||.:|       ...|.||         |.|||       |:.:..
Frog   747 IESPN--LGFTGELLLSNLQEDDL-------GHLSDLD---------PEPDAQNWQHTVGRDVAL 793

  Fly    71 --------RRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTLLFGQI-EM--IHNL 124
                    |::.|.|:..:|.|:|..|.:|...|.:.::::.::......|:|..: |:  |||.
Frog   794 HLLPKERARQEVIHELFVTEASHLRVLRVLDLIFYQRMRKENLLTPDELWLVFPNLPELIEIHNS 858

  Fly   125 NGEFLRELE--------------ANMENVAHAFLKM-APFFKLYSVYAFDYRGALFIIQDLISKN 174
            ..|.::.|.              ...:..|...::| |..|..|.:      .||.:|:....|.
Frog   859 LAESMKRLREEGPVIKEIGDLMLLRFDGAAGEEVRMEAAKFCSYQI------SALELIKAKKRKE 917

  Fly   175 PVFRKFLEQTESRPEVQR-KLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADY------------ 226
            ..|..|:::.||.|:.:| :|..|::..:||:.:|.||||.||.:|.....::
Frog   918 TRFSLFMQEAESNPQCRRLQLKDLIVSEMQRLTKYPLLLENVLKHTESGTQEHEKLYRCRDRCRD 982

  Fly   227 --KLLKESVKEIEATASHINTCVEEQEITQY-----LIHLQ---NSLVNRTPNIVKPSRRVIKEG 281
              |.:.||||:.|          .|..:.:|     ..||:   |.|.....|:...:||:|.||
Frog   983 ILKFVNESVKQAE----------NEHRLAEYQKRLDASHLERSNNPLAAEFKNLDLTTRRMIHEG 1037

  Fly   282 VLQ-KITHKGTEIKRYCVLMSDIFMYC-----KMIKERAPNTVVENSLECCCIFPLKKCKVYEML 340
            .|. ::..|..::  :.:|:.|:.:..     |::.:....|..:.......:..|....|..:.
Frog  1038 PLTWRVRDKTIDL--HVLLLEDLLVLLQKQDEKLVLKCHSKTTTDTKQTFSPVIKLNSVLVRSVA 1100

  Fly   341 PGNFKL--TCQSDGIIFGSGDVQL-------SRTWVGFIRDAID--LHVQCRKTLRKDSSKRTP- 393
            .....|  .|.||   .|....:|       ..||:..:.:|.:  :......|.||......|
Frog  1101 TDKKALFIICTSD---LGPQIYELVALTSSEKNTWMDLLEEATNGAMRNPPGATKRKSQDINRPT 1162

  Fly   394 -----IRKKDMKKFGADYVLSPNKRKCEY-------------DTVFRNKNRSTDSEEETEDSACF 440
                 :::..|.|..|:.||..|....:.             |.|.....|..|.::|.......
Frog  1163 SASMVLQRAHMPKLTAEGVLRHNSEDPQSGDEGAGEFLGQKPDVVLEEPEREDDEDDEARTPTLL 1227

  Fly   441 ---SRKRKVASGILRAPNGNPM---------GKASSSSSSSVSMKR------------------- 474
               |::.....|.....:.|.:         |.|.|:.....:::|
Frog  1228 PIPSKEEDAGGGTRGLDSSNHIPYHWPEVTEGLAESALDDVHNLRRLILKNMLHHGHSEYDSSSA 1292

  Fly   475 -VAPPPPAPPPPPAVQMRHQPGRP-------------GELATASKENRISKLYKKIAAGDKVANV 525
             ||.|.....|.|:|...|  |.|             .:..|..||..:|          :..:.
Frog  1293 PVAEPEDDLTPTPSVIGGH--GHPWDTMTDAVLENLDADQTTEEKETSVS----------RSESS 1345

  Fly   526 RGILK--RSNVPAPNNDHDPSYGFASRYSDSKS---------YFRAHN------------VDN-- 565
            |.:|.  ....|...:..:.::....||..|.|         :...||            |.|
Frog  1346 RSVLNFPHGERPGSRDGEETAWSLVERYPQSSSVQQNQSEQLHSEDHNNRSYRVVRKAEVVGNYD 1410

  Fly   566 --TIP-----------------------------TFVKR-----EDLFNGDNM-FPVHLKSHE-- 591
              ::|                             |..|.     |.|.|.|.: .|..|:|.|
Frog  1411 VISLPDSSQSQSVLQEAGGGAIVDGNFFYVTASATSTKEDPEVSESLTNSDRLSSPSFLESRESN 1475

  Fly   592 -------EICTPPQKKRVKFDDTL-DAVSPVLV 616
                   |..|||.:. .:.|..| |.:.|.||
Frog  1476 HTPTYQSEFSTPPPRS-TESDPLLSDLLPPKLV 1507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	49/202 (24%)
		PH-like	269..>311	CDD:302622	11/47 (23%)
		PH	277..374	CDD:278594	19/111 (17%)
arhgef11	XP_017952119.2	PDZ_signaling	63..137	CDD:238492
		RGS	357..501	CDD:413378
		RhoGEF	805..989	CDD:214619	44/189 (23%)
		PH_PRG	1006..1143	CDD:275426	27/141 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910