DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF4 and fgd1

DIOPT Version :9

Sequence 1:NP_648101.1 Gene:RhoGEF4 / 38806 FlyBaseID:FBgn0035761 Length:647 Species:Drosophila melanogaster
Sequence 2:XP_004914246.1 Gene:fgd1 / 100489369 XenbaseID:XB-GENE-6453246 Length:913 Species:Xenopus tropicalis


Alignment Length:462 Identity:115/462 - (24%)
Similarity:197/462 - (42%) Gaps:108/462 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IHSPQT--PLSFSRELRQVLQERNLLTAKSRRKVCSMLDSNNSSPIGSPNPDAG----KRLG--- 69
            |.||.|  .:.|..|:.:..:|.: .|..|..:.||..||...|.:...:.|.|    :||.   
 Frog   270 ISSPSTSEEMCFLGEVDEGGREES-ETCYSVAQRCSARDSEGDSDMEDGSGDEGELPPERLDPCE 333

  Fly    70 -FRRQAI----QEIISSEKSYLEQLELLMNFFVRPLKEQAIIDCSNHTL----LFGQIEMIHNLN 125
             ..||.:    .|::.:||:|:.:|.||...|...|.::|....|....    :|..|..|:..:
 Frog   334 FTARQKVYKIANELLQTEKAYVSRLHLLDQVFCARLMDEARTRASFPVEVVMGIFSNICSIYCFH 398

  Fly   126 GEF-LRELEANME------NVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKFLEQ 183
            .:| |.|||..|:      .:.....|:|||.|:|..|..::..|:.::.....::..|:..:: 
 Frog   399 QQFLLPELEKRMQEWDSNPRIGDILQKLAPFLKMYGEYVKNFDRAMELLNVWTERSSQFKSVIQ- 462

  Fly   184 TESRPEVQRK-------LNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESVKEIEATAS 241
                 ||||:       |...|:.|:||:|||:|||:..|| ..|.|:..:...|...|:.|||:
 Frog   463 -----EVQREEACGNLTLQHHMLEPVQRIPRYELLLKDYLL-KLPEDSKDRCDAEKSLELIATAA 521

  Fly   242 -HINTCVEEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHK-GTEIKRYCVLMSDIF 304
             |.|..:.:.|....|:.:. .|:....:||.|:..:||||.:.|::.| ||...||.:|.:|..
 Frog   522 EHSNAAIRKMERMHKLLKVY-ELLGGEEDIVSPTNELIKEGHILKLSAKNGTTQDRYLILFNDRL 585

  Fly   305 MYC----KMIKER------------------APNTVVENSLECCCIFPLKKCKVYEMLPGNFKLT 347
            :||    ::|.::                  :||                       |...|:::
 Frog   586 LYCVPKLRLIGQKYSVRARIDVEGMELKHSSSPN-----------------------LTRTFRVS 627

  Fly   348 CQSDGIIFGSGDVQLSRTWVGFIRDAIDLHVQ----CR---KTLRKDS-----------SKR--T 392
            .:...:...:...:..:.|:..|...|:.|.|    |:   .::|:|.           .||  |
 Frog   628 GKQRSLELQARTEEEKKDWIQAIEATINRHEQAMESCKLLCTSIREDEETPPNSPNTDLGKRAPT 692

  Fly   393 PIRKKDM 399
            |||:|::
 Frog   693 PIREKEV 699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF4NP_648101.1 RhoGEF 74..244 CDD:279015 54/192 (28%)
PH-like 269..>311 CDD:302622 17/46 (37%)
PH 277..374 CDD:278594 21/119 (18%)
fgd1XP_004914246.1 PHA03247 <6..207 CDD:223021
RhoGEF 341..525 CDD:238091 54/190 (28%)
PH1_FGD1 557..664 CDD:275392 24/129 (19%)
FYVE_FGD1_2_4 691..755 CDD:277280 5/9 (56%)
PH2_FGD1-4 780..885 CDD:270056
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm49235
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X316
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.910

Return to query results.
Submit another query.